October 13, 2016
2:35 pm – 2:50 pm
By Daniel Himmelstein
Slides at slides.com/dhimmel/graphconnect
Hetionet is a hetnet — a network with multiple node and relationship types. Version 1.0 contains 47,031 nodes of 11 types and 2,250,197 relationships of 24 types. Data was integrated from 29 public resources to connect compounds, diseases, genes, anatomies, pathways, biological processes, molecular functions, cellular components, perturbations, pharmacologic classes, drug side effects, and disease symptoms.
Hetionet was created as part of Project Rephetio, an open science project to systematically identify why drugs work and predict new therapies for drugs. Using advanced Cypher queries, we quantified the network connectivity between drug–disease pairs along 1,206 types of paths. We then used machine learning to predict the probability of treatment for 209,168 compound–disease pairs.
Hetionet is available online as a public Neo4j database instance. The Hetionet Neo4j Browser includes an introductory guide as well as guides showing the most supportive paths for each of the 209,168 predictions. The Hetionet Browser uses Docker for Neo4j. Join us at GraphConnect to learn about how Neo4j is a powerful technology for human disease research.
multilayer network, multiplex network, multivariate network, multinetwork, multirelational network, multirelational data, multilayered network, multidimensional network, multislice network, multiplex of interdependent networks, hypernetwork, overlay network, composite network, multilevel network, multiweighted graph, heterogeneous network, multitype network, interconnected networks, interdependent networks, partially interdependent networks, network of networks, coupled networks, interconnecting networks, interacting networks, heterogenous information network
networks with multiple node or relationship types
What's the best software for storing and querying hetnets?
GitHub stats from 2016-10-09
Visualizing Hetionet v1.0
Project online at thinklab.com/p/rephetio
See in the Neo4j Browser
Cypher query to find the top CbGbPWaD paths
|Hetionet Neo4j Browser||Neo4j Instance||neo4j.het.io|
|Cypher Tutorial for Project Rephetio||GraphGist||goo.gl/nO7wbU|
|Thinklab Project||Lab Notebook||thinklab.com/p/rephetio|
|More Cypher queries on Hetionet||Discussion||doi.org/brsd|
|My PhD Thesis Seminar on Hetnets||Video||youtu.be/H8DfXop8K7g|
A special thanks to: