Predicted protein associations from
Experimental protein associations from
As of September 2016, we have 39,870 active entries within our HGNC database of which 19,017 are for protein-coding genes.
Over the last three years:
The majority of HGNC's human gene symbols have become or are becoming well entrenched in the literature and databases, and should never require reassignment.
HGNC limit the number of symbol alterations and only ever change symbols for specific reasons, the most common being if a symbol can be updated from an uninformative placeholder designation, such as our C$orf#s, KIAA# or FAM#s, or if the symbol was originally assigned based on information that has since been found to be erroneous and the existing symbol could be misleading. To avoid symbol changes but improve our nomenclature we can make updates to gene names while retaining the symbols, for example, to remove references to other species or human-specific phenotypes.
Motivation: I recently used a hack to group genes.
Genes are grouped into families based on homology or a shared characteristic such as a common function and/or phenotype, or membership of a complex. We have also begun curating the relationships between different gene families, for example, the protein phosphatase gene family members represent a subset of the phosphatases gene family.
See also https://doi.org/bw6j
Gene family reports often feature a description of the family, which may be sourced from Wikipedia, UniProt, a publication, or may be written by an HGNC curator or specialist advisor.
Database licensed as CC BY-SA, drugcentral.org
|Molecular function (MF)||10,417||14,039|
|Cellular component (CC)||4,022||7,854|
|Biological process (BP)||29,146||71,372|
The GO describes function with respect to three aspects: