Autism Genetic Methods

TADA

  • Transmission and De novo Association Test (2013)

  • Bayesian method aggregating gene-level association signal from common variation, rare inherited mutations, & de novo mutation

ASD.Princeton

  • Machine learning approach (2016)
  • Uses GIANT database brain-specific gene annotations as features (includes coexpression, perturbation experiments, etc.)
  • Provide genome-wide gene-level estimates of autism involvement

DAMAGES

  • Machine learning approach (2017)
  • Uses pLI and cell-type specific expression profiles to provide genome-wide gene-level autism involvement scores
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