legacy code
You just have to deal with it,
all of it
Index
Intro
The human body is a plateforme with a lot of features.
The DNA is its codebase.
When hearing Genetic mutation, you think about...?
Modification/alteration of the genetic code
Often harmless
Sometimes pathogenic
(The Weasleys)
a. Red heads
(WOLVERINE : claws, super fast healing)
b. X-MEN
(Anton Yelchin "Pavel Chekov", cystic fibrosis)
c. Disorders
What's a gene?
Chromosome section determining hereditary traits, such as a feature
e.g. blood types are determined by the ABO gene (with the A allele, B allele and O allele)
a.
b.
c.
THE PROD
Our body has no local env, nor staging, nor preprod.
Our body is
What do ANgelina jolie and i have in common ?
We're both carriers of a pathogenic variant on the BrCa1 gene
I have a bug in prod*
*But there's no incident yet
BrCa1 (Breast Cancer 1)
feature: tumor suppressor gene
"keeps genomic integrity to prevent an uncontrolled growth of cells. It regulates a cell during cell division and replication."
Breast
Cancer
Ovarian
Cancer
More
prostate, endometrium, colon
breast
ovaries
General population
Carrier of a BrCa1 mutation
10%
75%
40%
1%
risk factors for cancer
Someone, somewhere, forgot a closing bracket or a semicolon
🤬
And they git commit --no-verify to ignore the linter
C'est abusé.
Questions ?
💔
how?
A saliva sample
A hair sample
An nail sample
A urine sample
actually it's really simple :)
genetic Testing
why?
My family history
1 blood test
+
1 blotting paper, to send after 1 month
waiting time for the results: 2 to 3 months
Now what?
THIS IS FINE.
Monitoring
(MRI, Mammogram, ultrasound)
Breasts
ovaries
PRAY. 🙏
(fate, god, the Universe, luck, anything)
kill high risk features
Maintenance
feature killing and bugfixing
Prevent incidents on the BrCa1 scope.
– Me, since 2019
Trigger Warning: Medical raw content
1
Backup of the genetic code
Fertility preservation
code Backup
"oocyte cryopreservation" = egg freezing
Summed up procedure
-
blood testings + ultrasounds
-
ovarian stimulation (hormones)
-
oocyte retrieval
Why?
- Useful if feature kill for feature "ovaries"before menopause
code Backup
- If planning a new app (baby),
we could chose the part of code that's not bugged !
chosing unbugged code in detail
1 oocyte = 1 cell
contains 1 chromosome of each pair
code Backup
after an in vitro fecundation (FIV), they can retrieve 1 cell and analyse it
→ preimplantation diagnosis
*not systematic, on an individual basis
could have mum's healthy chromosome 17
could have dad's f*cked up chromosome 17
Questions so far?
1
Backup of the genetic code
2
Backup of the genetic code (again)
3
Killing the BOOBS feature
BILATERAL MASTECTOMY
with immediate PAP flap reconstruction
Kill the boobs feature
BILATERAL MASTECTOMy
TASK DURATION & KR
- 12 hours (+3) in the operating room
- 8 drains, 2 perfusions, 2 monitors
- 4 days until I was able to get up
- 2 months recovery
Reducing the technical debt
- Mammary tissue removal
- flap excision
- Grafting (microsurgery)
BILATeRAL mastectomy
💪
The ticket is in prod
- 70cm of cumulated scars
-reconstruction status: hideous
but it's a Work In Progress
Risk went below 5%
3
Killing the BOOBS feature
4
Bug fixing & clean
after killing BOOBS feature
1
Backup of the genetic code
2
Backup of the genetic code (again)
2nd STAGE SURGERY
BUGFIX & clean
CONTINUING THE reconstruction
Task duration & KR
- 2 hours in the operating room
- completely bruised thighs
- 2 to 3 weeks recovery
- 6 stitches
Reconstruction status: much better, but still unpleasant
BUGFIX & clean
- Scar revision & flap burying
- Fat grafting to soothe ripples and gaps
↑
paracetamol life
5
Killing the OVARIES feature
3
Killing the BOOBS feature
4
Bug fixing & clean
after killing BOOBS feature
1
Backup of the genetic code
2
Backup of the genetic code (again)
BILATERAL SALPINGO-OOPHORECTOMY
usually recommended after 40 yo.
(but not for me)
Killing OV'
BILATERAL SALPINGO-OOPHORECTOMY
TASK DURATION & KR
- 2 hours in the operating room
- 2 to 3 weeks recovery
Reducing the technical debt
- Removal of ovaries & fallopian tubes
BILATERAL SALPINGO-OOPHORECTOMY
The ticket is in prod
- Menopause
→ 15+ years of Hormone Replacement Therapy (HRT medication)
💪
Risk went below 2%
6
Bug fixing after killing BOOBS feature
5
Killing the OVARIES feature
3
Killing the BOOBS feature
4
Bug fixing & clean
after killing BOOBS feature
1
Backup of the genetic code
2
Backup of the genetic code (again)
2nd STAGE SURGERY
(BIS)
BUGFIX
CONTINUING THE reconstruction
TASK DURATION & KR
- 2 hours in the operating room
- fully bruised thighs
- 2 to 3 weeks recovery
- 13 stitched
Reconstruction status: not perfect, but will do
CLEAN & BUGFIX
- Fat grafting to soothe ripples, gaps and try to even out asymmetry
↑
paracetamol life
Maintenance
what about mental health?
Keep afloat
– Still me, since 2019
Meet all the doctors in the shortest
amount of time
CONTEXT SWITCHING
Irreversible life and body changes
DECISION MAKING
Conclusion
Connaissez vos antécédents familiaux !
Savoir, c'est pouvoir décider.
ça fait + de 10 ans que je sais
j'ai passé 8 ans à monitorer, la boule au ventre
backup
2 ans à fixer
2011
2022