From structure to function: leveraging embedded multimodal imaging to explore brain connectivity
| smoia | |
| @SteMoia | |
| s.moia.research@gmail.com |
Maastricht, 31.10.2024
Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands; physiopy (https://github.com/physiopy)
Stefano Moia, 2024
From structure to function: leveraging embedded multimodal imaging to explore brain connectivity
Maastricht, 31.10.2024
Blood Oxygen Level Dependent (BOLD) signal
Image courtesy of Dimo Ivanov
BOLD signal: "Functional Networks"
Biswal et al., 1995 (Magn. Reson. Med.)
r(X, Y) = \frac{\text{cov}(X, Y)}{\sigma_X \sigma_Y}
Pearson correlation:
Whole brain functional connectivity
Huang et al., 2018 (Proc. IEEE)
From timeseries to graphs
x1
x2
x3
x8
...
t
y
t=1
x1=y1
From timeseries to graphs
x1
x2
x3
x8
...
t
y
t=2
x2=y1
From timeseries to graphs
x1
x2
x3
x8
...
t
y
t=3
x3=y1
From timeseries to graphs
x1
x2
x3
x8
...
x1
x2
x3
x8
...
x1
x2
x3
x8
...
From timeseries to graphs
x1
x2
x3
x8
...
x1
x2
x3
x8
...
x1
x2
x3
...
x8
t=1
x1=y1
From timeseries to graphs
x1
x2
x3
x8
...
x1
x2
x3
x8
...
x1
x2
x3
...
x8
t=2
x2=y1=x1_{t1}
From timeseries to graphs
x1
x2
x3
x8
...
x1
x2
x3
x8
...
x1
x2
x3
...
x8
t=3
x3=y1=x2_{t2}
x_{k_{t}}=\sum x_{j_{t-1}}
Graph Signal Processing
Ortega 2022 (Introduction to Graph signal Processing)
Preti et al. (2019) Nat. Commun.; Huang et al. (2018) Proc. IEEE
Graph Signal Processing: Filtering
Decomposition
to access
"graph" spectral domain
NiGSP is an open development (python) toolbox to apply
Graph Signal Processing on neuroimaging data
It offers a set of function for filter creations, filtering, visualisation,
and metrics computations
Applying Graph Signal Processing: NiGSP
Moia et al. (2023) Zenodo
Preti et al. (2019) Nat. Commun.; Griffa et al. (2022) Neuroimage; Forrer et al. (2024) Biol. Psychiatry
pip install nigsp[all]
nigsp -f timeseries.nii.gz -s sc_mtx.tsv -a atlas.nii.gz --informed-surrogates -n 1000Moia et al. (2023) Zenodo; based on Preti, Van De Ville (2019) Nat. Commun. and Griffa et al. (2022) Neuroimage
Applying Graph Signal Processing: NiGSP
Sneak peak
BOLD
Neuronal
fluctuations
Physiological
fluctuations
Disentangling fluctuations with GSP
Thanks to...
That's all folks!
| smoia | |
| @SteMoia | |
| s.moia.research@gmail.com |
...you for the (sustained) attention!
...the MR-methods group @UM
Part of this research is supported by the European Union’s Horizon Europe research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101109770
Stefano Moia, 2024
Find the presentation at:
slides.com/ephraim24/mbic-multimodal-connectivity/scroll
...the MIP:Lab @ EPFL
Any question [/opinions/objections/...]?
From structure to function: leveraging embedded multimodal imaging to explore brain connectivity
By Stefano Moia
From structure to function: leveraging embedded multimodal imaging to explore brain connectivity
CC-BY 4.0 Stefano Moia, 2024. Images are property of the original authors and should be shared following their respective licences. This presentation is otherwise licensed under CC BY 4.0. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
