Neural networks for volitional movement generation
evidence from neuroimaging meta-analysis
Felix Hoffstaedter, Robert Langner, Simon Eickhoff
Institute of Neurosciences and Medicine (INM-7)
Forschungszentrum Jülich
Content
Volitional Movements
- min 2 alternative choices not determined by the experiment
- resulted in a movement response
Neuroimaging Meta Analysis
Co-ordinate based meta-analysis
Activation likelihood estimation
Index
N = 35 17 female
Age = 35.9 ± 12.4
3T Siemens Trio 33min
Volitional Timing & Choice
Volitional Choice
Non-Volitional
Subtraction of neural activation in fMRI
Choice > Reaction = What
Timing > Choice = When
The Turing Way project illustration by Scriberia. Used under a CC-BY 4.0 licence. DOI: The Turing Way Community & Scriberia (2024).- synthesis of quantitative data from multiple independent studies addressing a common research question
- computing a combined effect size across studies
Meta-analysis
- synthesis of quantitative data from multiple independent studies addressing a common research question
- computing a combined effect size across studies
Meta-analysis
- Analytical flexibility: Effect sizes are difficult to compare
- Data sharing is rare: Mega-analyses are very rare
Neuroimaging Meta-analysis
- synthesis of quantitative data from multiple independent studies addressing a common research question
- computing a combined effect size across studies
Meta-analysis
- Analytical flexibility: Effect sizes are difficult to compare
- Data sharing is rare: Mega-analyses are very rare
Neuroimaging Meta-analysis
Co-ordinate Based Meta-analysis
Co-ordinate Based Meta-analysis
| ‘What’ | MNI coordinates | |||
|---|---|---|---|---|
| pre-SMA | Area 6 | 3141 | 0 / 17 / 50 | |
| dPMC | Area 6 | R | 20 / 3 / 62 | |
| dPMC | Area 6 | L | 348 | -20 / -2 / 65 |
| DLPFC | - | R | 337 | 32 / 47 / 21 |
| DLPFC | - | L | 1054 | -38 / 47 / 12 |
| Broca’s Area | Area 45 | -41 / 35 / 15 | ||
| IPL | PF | L | 382 | -57 / -39 / 36 |
| IPS | hIP1 | -39 / -45 / 38 | ||
| hIP2 | -51 / -41 / 39 | |||
Co-ordinate Based Meta-analysis
| ‘What’ | MNI coordinates | |||
|---|---|---|---|---|
| pre-SMA | Area 6 | 3141 | 0 / 17 / 50 | |
| dPMC | Area 6 | R | 20 / 3 / 62 | |
| dPMC | Area 6 | L | 348 | -20 / -2 / 65 |
| DLPFC | - | R | 337 | 32 / 47 / 21 |
| DLPFC | - | L | 1054 | -38 / 47 / 12 |
| Broca’s Area | Area 45 | -41 / 35 / 15 | ||
| IPL | PF | L | 382 | -57 / -39 / 36 |
| IPS | hIP1 | -39 / -45 / 38 | ||
| hIP2 | -51 / -41 / 39 | |||
~ 10k studies reporting co-ordinated
Co-ordinate Based Meta-analysis
Co-ordinate Based Meta-analysis
Neural Network for
volitional movements generation
Neural Network for
volitional movements generation
- 78 fMRI & PET experiments
- 49 non-volitional control conditions
- 47 choice conditions
- 36 timing conditions
- Task-set effects: PET & fMRI block-design
- 26 choice - sustained activity
- 22 timing - sustained activity
- Event-related fMRI modeling:
- 11 Preparation
- 17 Execution
Neural Network for
volitional movements generation
Neural Network for
volitional movements generation
Neural Network for
volitional movements generation
Neural Network for
volitional movements generation
Neural Network for
volitional movements generation
Conclusion
- Generalized networks for volitional movements
- Choice // Timing
- Preparation & Execution
- Choice // Timing
- Neuroimaging Meta-analysis reveal new findings
- FAIR science is good science
- DataLad helps with RDM
INM-7 f.hoffstaedter@fz-juelich.de