Mechanistic Knowledge
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Novel Machine Learning
Problem: Can we predict the next pandemic?
Can we predict future mutations? Can we define the "edge of emergence"?
Emergenet: Generative model of emergenet rules of organization
Bio_NORAD
Validation Against IRAT Scores
Predicting diffusion rate in strain space
New metrics of immunological vulnerabilities
Who Cares?
Allows rapid reliable prediction of future mutations, variants and rank orders strains by their pandemic risk. Can target viruses BEFORE the first human infection
What is the new approach?
Learn deep generative models of emergent dependencies acoss non-colocated residue variations, which induce a biology aware metric
What are we trying to do?
Develop future-proof vaccines and countermeasures, escape-resistant to emergence of variants and zoonosis
Immunological and structural information
Chattopadhyay, Ishanu, Kevin Wu, Jin Li, and Aaron Esser-Kahn. “Emergenet: Fast Scalable Pandemic Risk Assessment of Influenza A Strains Circulating In Non-Human Hosts,” December 23, 2022. https://doi.org/10.21203/rs.3.rs-2336091/v1.
ishanu Chattopadhyay
Rick Stevens
Aaron Esser-Kahn
Paul Bogdan
S. Gnanakaran
Paul Bogdan
Future-proof Countermeasures