Acknowledgements
Monies!
NSF CAREER (CBET-1351692), NSF BRAIN
EAGER (IOS-1550994), HFSP Young Investigator’s (RGY0088)
Lab
Dr. Caleb Kemere
Josh, Ziying, Sibo, Della, Kayla, Dani, Amy
Former: Jim, Ariel, Etienne, Alex, James, Jill, Eric
Interrogating the role of hippocampal sharp-wave ripples in spontaneous learning
Shay(ok) Dutta
Interface Rice 2023
May 19, 2023
Will Smith...
What is the neural substrate for storing the configuration of the world?
Will Smith --> Rats
What is the neural substrate for storing the configuration of the world?
Where to begin?
Active Behavior
Quiescence
hmm...
Where to begin?
Quiescence
hmm...
Active Behavior
What does this look like?
Just Rat Hippocampus
Are SWRs related to storing the configuration of the world?
How can we test this?
Dutta et al. JNE 2018
ORM No More!
Are SWRs related to storing the configuration of the world?
YES!
Conclusions
Cool stuff! Come check out poster 9!
- Causal relationship established between hippocampus and object-location memory
- First ripple disruption task that can be run repeatedly with chance level performance!
- New memory formation, consolidation and place field stability questions can be asked!
- First ripple disruption task with result with a behavioral effect that is in shown in a natural, foraging, curiosity driven behavior innate across animals!
- Longer ripples clearly have some relationship with better memory consolidation but all ripples are matter for consolidation!