Trang Le: an introduction

Private Evaporative Cooling
(privateEC)

Tree-based Pipeline Optimization Tool
(TPOT)

STatistical Inference Relief
(STIR)

Nearest-neighbor Projected Distance Regression
(NPDR)
...

Creative Commons license CC0

select voxels/ROIs

structural MRI

predicted brain age

DNA-methylation

epigenetic age

- real age

- real age

automated ML

\Delta

epigenetic age

(regularized NPDR)

 ~  genetic variants

epigenetic age

\Delta

Dimensions and stages of aging

Aim 3

Aim 2

Aim 2 + 3

select CpG sites

time

automated ML

brain age

\Delta

brain age

\Delta

Aim 1

Develop and evaluate NPDR

select voxels/ROIs

structural MRI

predicted brain age

DNA-methylation

epigenetic age

- real age

- real age

automated ML

NPDR

\Delta

epigenetic age

NPDR

(regularized NPDR)

 ~  genetic variants

epigenetic age

\Delta

Dimensions and stages of aging

Aim 3

Aim 2

Aim 2 + 3

select CpG sites

time

automated ML

brain age

\Delta

brain age

\Delta

Aim 1

\(allele_i \) carrier

\(allele_i \) non-carrier

time

composite \(\Delta\) age

Application: BrainAGE

simulation, correction, ibuprofen

RNASeq

Flash CV

By Trang Le

Flash CV

A 5-minute presentation to briefly introduce my work in joint lab meeting with Li Shen and Yong Chen.

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