Mechthild Lütge, PhD
Bioinformatician with a specialization in:
- Omics Data analysis
- Immunology + Cancer biology
Interests: Sports, Mountains, Politics
2013
B.Sc. in Molecular Biotechnology
Cellular regulation in Glioblastoma:
- linear modelling of gene expression
2017
M.Sc. in Molecular Biotechnology
Specialization in Bioinformatics
University of Heidelberg (2010-2017)
Specialization in Bioinformatics
Bacterial pan-genomes:
- functional annotation
- co-occurrence analysis
- selective pressure analysis
2018
2024
PhD at the University of Zurich
Cantonal hospital St.Gallen (2018-2024)
Bioinformatics, Immunology
Moved to St. Gallen
>30 projects:
scRNAseq (10X, smartSeq), scVDJ, spatial transcriptomics (Visium), microbiome data (16S) and metagenome data
Immune cell niches
- Stromal cell niches across human and murine lymphoid organs
- Cellular interactions in immune cell niches
Single cell transcriptomics:
- pipeline for automated mapping/pre-processing
- establish routines for independent data exploration and standardize analyses
- data management
2024
Roche Pharma Research and Early Development
Started as a Postdoc in Oncology Discovery
Tumor Archetypes in Solid Tumors
- Machine learning models for tumor classification
- Pathway-based tumor subtyping
- Integration of transcriptome and image-derived features
Single cell and bulk RNAseq data, H&E imaging data, Clinical data and large real-world datasets