"Sample sizes are never large. If N is too small to get a sufficiently-precise estimate, you need to get more data (or make more assumptions).
But once N is 'large enough,' you can start subdividing the data to learn more (for example, in a public opinion poll, once you have a good estimate for the entire country, you can estimate among men and women, northerners and southerners, different age groups, etc.).
N is never enough because if it were 'enough' you'd already be on to the next problem for which you need more data."