• Hetnet of biology designed for drug repurposing
   
• ~50 thousand nodes
  11 types (labels)
   
• ~2.25 million relationships
  24 types
   
• integrates 29 public resources
  knowledge from millions of studies
   
• the hardest part:
  licensing of publicly available data

Hetionet v1.0

Visualizing Hetionet v1.0

https://neo4j.het.io/browser/

https://github.com/dhimmel/hetionet

Future: all biomedical knowledge in a single network

https://github.com/greenelab/snorkeling

• Teach computers how to read the literature and extract knowledge.
   
• Continuously and automatically refine and grow the hetnet.
   
• Free from any legal restrictions on reuse. 

Does bupropion treat nicotine dependence?

• Bupropion was first approved for depression in 1985
   
• In 1997, bupropion was approved for smoking cessation
   
• Can we predict this repurposing from Hetionet? The prediction was:
  • 99.5th percentile for nicotine dependence
  • probability 2.50-fold greater than null

Compound–causes–SideEffect–causes–Compound–treats–Disease

Compound–binds–Gene–binds–Compound–treats–Disease

Compound–binds–Gene–associates–Disease

Compound–binds–Gene–participates–Pathway–participates–Disease

Epilepsy predictions

(browse all predictions at het.io/repurpose)

Discuss at thinklab.com/d/224

Evaluating the top 100 epilepsy predictions

Discuss at thinklab.com/d/224#5

Which target genes supported the top epilepsy predictions?

Online at thinklab.com/d/230#11