July 8, 2015
Daniel Himmelstein
Sergio Baranzini Lab
network of pathogenesis:
classifier:
mechanisms of pathogenesis:
gold standard for our supervised approach
aggregated 4 resources:
MEDI-HPS – combines RxNorm, MedlinePlus, SIDER 2, and Wikipedia
ehrlink – linked data from health records
LabeledIn – expert and MTurk curated drug labels
PREDICT – UMLS links, drugs.com, drug labels
1,388 high and 1,114 low-confidence indications
We combine all signatures for each DrugBank compound to get a consensus signature
http://thinklab.com/d/67
Bgee
curates microarray and RNA-Seq experiments
http://bgee.unil.ch/
TISSUES
transcriptomics, proteomics, text mining, UniProtKB
http://tissues.jensenlab.org/About
http://thinklab.com/d/81
http://thinklab.com/d/81#293
http://thinklab.com/d/81#293
depletion is more common than enrichment
highly-specialized tissues have the greatest differential expression