Discovery consists of seeing what everybody has seen and thinking what nobody has thought.
1933 Madison, Wisconsin
•During a howling blizzard, a Wisconsin farmer - Ed Carlson appeared with a dead cow and a milk can full of blood that would not clot. He was trying to find a vet whose office was not closed
•The first open building was Dr Link’s biochemistry building
•The farmer has been feeding his cattle with the only hay that he had – spoiled sweet clover
Dr Link and “sweet clover disease”
1939
Dr Link isolated dicoumarol, which is formed from coumarin produced by clover after interacting with fungi, as in the case of rotten clover
1948
Dr Link
1954
Endo Laboratories produced the first version of warfarin intended for human use, with the drug gaining popularity after being used to treat US president Eisenhower following a heart attack
Discovery consists of seeing what everybody has seen and thinking what nobody has thought.
The 1950’s
Dr Mason Sones Jr, Cleveland Clinic
•On oct 1958 Dr Sones was working on a 26 YOF, with RHD
•His assistant inserted the catheter into brachial artery and directed it up through the aorta towards the heart.
•Sones was monitoring the progress from under the table, on the fluoroscopic TV screen
•From under the table he had no control of the catheter and his assistant could not see the xray images
•From under the table he called “ inject”
•Then he watch in horror as the tip of catheter flipped around and 30 milliliters of dye was injected into the RCA, which was superbly visualized
•Fearing a cardiac arrest he yelled “ Pull it out , “we are killing her”, being ready to open her chest with a scalpel
•Patient had no heart beat for several frighthening seconds.
•Sones yelled at the patient: “ cough, goddamn it”
•Patient scared…coughed
•His heart started again, without any further complications.
1958, Dr Mason Sones Jr, Cleveland Clinic
Pionneer of angiography