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Javier Garcia-Bernardo   


About me



Always wanted to help the others:

- Instructor

- TA

- books4equality

- bike shop

My last semester of my master in Computer Science




Why volunteering?

How can I help?

Ready?

Downstream Gene Expression

Small fluctuations in Activator

Coordination

 

Coordination is good

Noise in Gene Expression


Intrinsic: Affect to only one gene.

E.g. RNApolymerase binding to a promoter

Inherent to the Gillespie Algorithm


Extrinsic: Affect to all genes

E.g. Fluctuations in the levels of the RNApolymerase

Modelled with a Ornstein–Uhlenbeck process




Emergence of Coordination

from noise in gene expression


TATA box example


Lots of genes in stress response in yeast have a TATA box.

Is that advantage due to coordination?

Has noise evolved?

Wow

Conclusions


Small fluctuations in the Activator

coordinate expression of Downstream genes.


Even Infrequent coordination helps to bet-hedge

against sudden changes in the environment.


They do this without cost (Not shown).


Noise can produce the fluctuations.