Autism Genetic Methods

TADA

• Transmission and De novo Association Test (2013)

• Bayesian method aggregating gene-level association signal from common variation, rare inherited mutations, & de novo mutation

ASD.Princeton

• Machine learning approach (2016)
• Uses GIANT database brain-specific gene annotations as features (includes coexpression, perturbation experiments, etc.)
• Provide genome-wide gene-level estimates of autism involvement

DAMAGES

• Machine learning approach (2017)
• Uses pLI and cell-type specific expression profiles to provide genome-wide gene-level autism involvement scores