Six ossification centers:
Head
Neck
Lesser Trochanter
Greater Trochanter
Intertrochanteric Line
Head
Neck
Lesser Trochanter
Greater Trochanter
Intertrochanteric Crest
Gluteal Tuberosity
Pectineal Line
Head
Fovea Capitis
Lesser Trochanter
Intertrochanteric Line
Medial Supracondylar Line
Lateral Supracondylar Line
Linea Aspera
Gluteal Tuberosity
Patellar Surface
Medial Epicondyle
Lateral Epicondyle
Adductor Tubercle
Medial Condyle
Medial Epicondyle
Lateral Epicondyle
Adductor Tubercle
Medial Supracondylar Line
Lateral Supracondylar Line
Lateral Condyle
Intercondylar Fossa
,
Pathogen進入組織後,被dendritic cell吞噬,並在lymph node呈現出來
Th cell binds to dendritic cell,dendritic cell釋放IL-12使Th1 cell成熟
成熟的Th1 cell釋放IL-2 和 IFN𝛄刺激其他Th1 cell變成 effector Th1 cell。而IFN𝛄也能刺激macrophage分泌 TNF, IL-1, IL-6等proinflammatory cytokines
Macrophage分泌的inflammatory cytokines會引發發炎反應,也就是紅腫熱痛
Macrophage 也會分泌其他物質造成tissue damage
Phagocytes (macrophage, neutrophils等) 遇到pathogens後進行胞吞作用,吞入的囊泡稱為 phagosome
Phagosome會和lysosomes結合形成phagolysosome,以摧毀pathogens
因為胞吞作用的關係,phagosome的膜和細胞膜結構一樣,含有NADPH Oxidase和Superoxide Dismutase
如果遇到不會被phagolysosome分解的pathogen (ex. 分解 NADPH Oxidase) ,那麼會促使更多phagocyte 和 T-lymphocyte 包圍pathogen
Phagocyte 釋放 IL-12, TNF𝛂,使Th成熟,而成熟的Th釋放TNF𝛄 刺激macrophage 繼續進行免疫反應
如此往復但是都沒辦法消滅被包圍起來的pathogen,即為Granuloma
CxR