Imaging Biomaterial-Tissue Interaction
Yu Shrike Zhang & Junjie Yao 2017 Oct 17.
- spatial resolution
- penetration depth
- temporal response
- detection sensitivity
- chemical specificity
engineering approaches
+
Ultrasound (US)
PRO
- safest
- high speed
- deep penetration
CON
- low resolution
- low chemical sensitivity
- coupling medium needed
Application
- mechanics
- flow dynamics
- scaffold cavitation
Magnetic Resonance Imaging (MRI)
PRO
- deep penetration
CON
- expensive
- low imaging speed
- strong magnetic field (unknown)
Application
- water content and transport
Optical Imaging
Confocal Microscopy (CM)
Multi-proton Microscopy (MPM)
Photoacoustic Tomography (PAT)
Optical Coherence Tomography (OCT)
High-energy Electromagnetic Waves
X-ray
Scanning Electron Microscopy (SEM)
Transmission Electron Microscopy (TEM)
Positron-emission Tomograph (PET)
Single-photon Emission Computed Tomography (SPECT)
限制
難以同時讓biomaterial 和biological entities成像
解決
exogenously introduced contract mechanism
為了形成對比，不同造影方法間的搭配與進展
近期的進步
CLARITY
&
Expansion Microscopy (ExM)
Conclusion
- 除了適當的contrast mechanism之外，還有很多辦法能提升影像清晰度
- the development of specialized multi-modality imaging systems and multiplexed contrast mechanisms