408510095 陳明皓
Expressed in mucosal tissues.
Forms dimers after secretion.
Constitutes only 10-15% of the total immunoglobulin in serum.
Serum IgA - monomer
Secretory IgA (sIgA)
Dimer (11S)
J chain
Secretory Component
Serves an effector function st mucous membrane surfaces (main entry sites for most pathogenic organisms).
Because it is polymeric, secretory IgA can cross-link large antigens with multiple epitopes
Binding of secretory IgA to bacterial and viral surface antigens prevents attachment of the pathogens to the mucosal cells.
Provide an important line of defense against pathogens.
Complexes of secretory IgA and antigen are easily entrapped in mucus and then eliminated by the ciliated epithelial cells.
A kidney disease that occurs when IgA builds up in your kidneys.
– IgA Nephropathy
啊就...尿出血來啦!