Understanding epidemiological and macroevolutionary processes using novel phylogenetic and phylodynamic methods
Nicola Felix Müller
Phylogenetic trees denote the evolutionary relationship between individuals
The shape of these trees tells us something about the population process that created them
Inferring how lineages coalesce within and migrate between sub-populations
- N. F. Müller, D. A. Rasmussen, T. Stadler (2017), Molecular Biology and Evolution.
- N. F. Müller, D. A. Rasmussen, T. Stadler (2018), Bioinformatics.
- N. F. Müller, G. Dudas, T. Stadler (2019), Virus Evolution.
Methods that allow accounting for population structure typically require to infer where lineages have been in the past
Müller et al., 2017, Mol. Biol. Evol.
Different approaches to integrate over migration histories can lead to vastly different inference results
Müller et al., 2017, Mol. Biol. Evol.
The marginal approximation of the structured coalescent of the structured coalescent allows accounting for population structure
Müller et al., 2017, Bioinformatics
MASCOT allows efficiently inferring where lineages were in the past, rates of migration between sub-populations and their population sizes
Müller et al., 2017, Bioinformatics
By defining rates of coalescence and migration as log-linear combinations of predictors data, indicators and coefficients, we can jointly infer migration and coalescence patterns and what predicts them
Müller et al., 2019, Virus Evolution
Inferring how lineages coalesce within and migrate between sub-populations
- N. F. Müller, D. A. Rasmussen, T. Stadler (2017), Molecular Biology and Evolution.
- N. F. Müller, D. A. Rasmussen, T. Stadler (2018), Bioinformatics.
- N. F. Müller, G. Dudas, T. Stadler (2019), Virus Evolution.
The shared evolutionary history of individuals from different species does not describe the history of species
The shared evolutionary history of individuals from different species does not describe the history of species