Assessment of functional vision for daily life locomotion and navigation using VR

M.A. Safa Andac

Prof. Dr. Michael Hoffmann

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 955590.

Section for Clinical and Experimental Sensory Physiology

Otto-Von-Guericke University Magdeburg

Mr. Müller

Mr. Müller

  1. solo traveler
  2. into science a bit
  3. reads between the lines

Mr. Müller

Mr. Müller

  1. Likes to travel (a lot!)
  2. Into science a bit
  3. Reads between the lines​
  4. glaucoma

Mr. Müller

  1. solo traveler
  2. into science a bit
  3. reads between the lines
  4. glaucoma

 

How well can I travel

considering the effect of glaucoma

on locomotion and navigation?

  • Mobility
  • Path Integration
  • Locomotion
  • Navigation

Outline

MOBILITY

  • Glaucoma: one of the common causes of blindness worldwide
  • Visual impairment increasing the risk of falling with age [1,2]
  • Reduced movement in people with vision loss [2]

PATH INTEGRATION

PATH INTEGRATION

  1. Start from Point 0
  2. Move to Point 1
  3. Remember the position
  4. Move to Point 2 (second waypoint)
  5. Move to Point 3 (final waypoint)
  6. Point the position to be remembered

1

2

3

0

14 Glaucoma

15 Control (age-matched)

Lighting Conditions

PI

Cohort

PATH INTEGRATION : METHODS

No group effect 

⇨

Accuracy

Euclidian Distance Error  [vm]

PATH INTEGRATION : results

No group effect 

⇨

Accuracy

Travel Time

Glaucoma is slower

⇨

Total Time for Travel [s]

Euclidian Distance Error  [vm]

PATH INTEGRATION : results

PATH INTEGRATION : results

No group effect 

⇨

Accuracy

Travel Time

Glaucoma is slower

⇨

Relation of time and pRNFL

⇨

Objective Relation

Total Time for Travel [s]

Total Time for Travel [s]

Euclidian Distance Error  [vm]

  • Insecurity in glaucoma patients makes them slower
  • Trade-off between time and accuracy
  • A possible relation between pRNFL and movement

PATH INTEGRATION : COnCLUSION

PATH INTEGRATION : COnCLUSION

Wait! I think I saw something

in the Figure 1

in the paper

  • Insecurity in glaucoma patients makes them slower
  • Trade-off between time and accuracy
  • A possible relation between pRNFL and time

Full trajectory of a glaucoma

PATH INTEGRATION : COnCLUSION -- 2

Full trajectory of a glaucoma

PATH INTEGRATION : COnCLUSION -- 2

Full trajectory of a glaucoma

PATH INTEGRATION : COnCLUSION -- 2

Full trajectory of a glaucoma

What might the figure show us?

  • Head sway
  • Body sway
  • Locomotion Pattern Change

PATH INTEGRATION : COnCLUSION -- 2

Full trajectory of a glaucoma

  • Head sway
  • Body sway
  • Locomotion Pattern Change

Is there any movement difference between glaucoma and control?

What might the figure show us?

PATH INTEGRATION : COnCLUSION -- 2

LOCOMOTION

  • Videos of 18 glaucoma and 30 control participants [1,2].
  • Ophthalmic examination (i.e. ETDRS, IOP, VF, OCT)
  • Measurements on treadmill at different speeds
    • Visual Acuity (VA), Contrast Sensitivity (CS),  Visual Field (VF)

LOCOMOTION: METHODS

LOCOMOTION : RESULTS

Classification using Videos in Visual Acuity Task

No difference between glaucoma and control

Classification using Videos in Visual Acuity Task

LOCOMOTION : RESULTS

LOCOMOTION : RECLASSIFICATION

  • The cohort includes early-stage glaucoma
  • PCA applied on OCT measures (retinal integrity)
  • Pick 10 extreme from each end

 

PCA Result

Glaucoma

Control

Re-Classification using Videos in Visual Acuity Task

LOCOMOTION : RESULTS

Relationship between movement and pRNFL

Re-Classification using Videos in Visual Acuity Task

LOCOMOTION AND GLAUCOMA : RESULTS

SUMMARY

  • Glaucoma is slower
  • No difference between early glaucoma and control in locomotion
  • BUT, a relation between pRNFL and movement

The locomotion changes in glaucoma might be reflected by pRNFL.

NAVIGATION

Locomotion

Navigation

NAVIGATION

Locomotion

Navigation

 Walter, Jasmin L., et al. “Finding Landmarks - An Investigation of Viewing Behavior during Spatial Navigation in VR Using a Graph-Theoretical Analysis Approach.” PLOS Computational Biology, vol. 18, no. 6, June 2022.

NAVIGATION

Westbrück Virtual City

Glaucoma

Analysis

NAVIGATION

Westbrück Virtual City

Glaucoma

Analysis

Simulation

Peripheral - Central Scotoma

ACKNOWLEDGEMENT

THANKS!

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 955590.

DZNE

Wolber's Lab

Prof. Thomas Wolbers

Prof. Erhardt Barth

Yaxin Hu

Prof. Peter König

Jasmin L. Walter

Dr. David Mann

Kirsten Veerkamp

ACKNOWLEDGEMENT

THANKS!

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 955590.

DZNE

Wolber's Lab

Prof. Thomas Wolbers

Prof. Erhardt Barth

Yaxin Hu

Prof. Peter König

Jasmin L. Walter

Dr. David Mann

Kirsten Veerkamp

ACKNOWLEDGEMENT

DZNE

Wolber's Lab

Prof. Thomas Wolbers

Prof. Erhardt Barth

Yaxin Hu

Prof. Peter König

Jasmin L. Walter

Dr. David Mann

Kirsten Veerkamp

THANKS!

ACKNOWLEDGEMENT

DZNE

Wolber's Lab

Prof. Thomas Wolbers

Prof. Erhardt Barth

Yaxin Hu

Prof. Peter König

Jasmin L. Walter

Dr. David Mann

Kirsten Veerkamp

THANKS!

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