Wernicke-Korsakoff syndrome

- thiamine deficiency 

wernicke-korsakoff syndrome

•  a spectrum of diseases resulting from thiamine deficiency 
• associated with chronic alcoholism 
  • alcohol bloch thiamine-transporter-1 

Wernicke-korsakoff syndrome

• Thiamine pyrophosphate serves as a coenzyme in: 
  • formation or degradation of alpha-ketols by transketolase
  • oxidative decarboxylation of 
    alpha-keto acids

Symptoms of wernicke-korsakoff syndrome

• Nystagmus and paralysis
   
• Ataxia
   
• Mental status complications 

Wernicke-korsakoff syndrome

• Exams and test
  • physical examination
  • serum albumin
  • serum B1 level
  • transketolase activity in RBC

wernicke-korsakoff syndrome

•  a spectrum of diseases resulting from thiamine deficiency 
• associated with chronic alcoholism 
  • alcohol bloch thiamine-transporter-1