ECP Data Collection

The Problem

A lot of the data was collected improperly
Seems that this could impact a fair number of publications

Cook, C. J. et al. Effective Connectivity Within the Default Mode Network in Left Temporal Lobe Epilepsy: Findings from the Epilepsy Connectome Project. Brain Connectivity 9, 174–183 (2019).

Hwang, G. et al. Using Low-Frequency Oscillations to Detect Temporal Lobe Epilepsy with Machine Learning. Brain Connectivity 9, 184–193 (2019).

Hwang, G. et al. Cognitive slowing and its underlying neurobiology in temporal lobe epilepsy. Cortex 117, 41–52 (2019).

Hwang, G. et al. Brain aging in temporal lobe epilepsy: Chronological, structural, and functional. Neuroimage Clin 25, 102183 (2020).

Hermann, B. et al. Network, clinical and sociodemographic features of cognitive phenotypes in temporal lobe epilepsy. Neuroimage Clin 27, 102341 (2020).

Bonet, C. N. R. et al. Neuroticism in temporal lobe epilepsy is associated with altered limbic-frontal lobe resting-state functional connectivity. Epilepsy Behav 110, 107172 (2020).

Struck, A. F. et al. Regional and global resting-state functional MR connectivity in temporal lobe epilepsy: Results from the Epilepsy Connectome Project. Epilepsy Behav 117, 107841 (2021).

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Size of the Problem

Every post-upgrade Madison session has functional scans collected in the same direction

Madison TLE Patients

38 pre

29 post

Individual Papers

Connectivity, 2019

looks at differences in connectivity between TLE and HC
Used Spectral Dynamic Causal Modeling
Final sample includes 34 participants
- 17 L-TLE and 17 Controls
- Both MCW and UW

Probably okay

Connectivity, 2019

Goal was to train ML classification models to discriminate TLE patients from healthy controls
- Wanted to know which resting state measure and frequency range produced the best classification model
Final sample includes 119 participants
- 60 TLE (29 L, 15 R, 4 Bilateral, 12 uncertain)
- Also took 12 controls from ADCP
Models included SVM, Linear Discriminant, naive bayes

Cortex, 2019

55 TLE patients and 58 healthy controls
All 71,631 connections were tested for their correlation with the age-corrected PCPS scores (using FDR correction)