Trang Le: an introduction
Private Evaporative Cooling
(privateEC)
Tree-based Pipeline Optimization Tool
(TPOT)
STatistical Inference Relief
(STIR)
Nearest-neighbor Projected Distance Regression
(NPDR)
...
Creative Commons license CC0
select voxels/ROIs
structural MRI
predicted brain age
DNA-methylation
epigenetic age
- real age
- real age
automated ML
epigenetic age
(regularized NPDR)
~ genetic variants
epigenetic age
Dimensions and stages of aging
Aim 3
Aim 2
Aim 2 + 3
select CpG sites
time
automated ML
brain age
brain age
Aim 1
Develop and evaluate NPDR
select voxels/ROIs
structural MRI
predicted brain age
DNA-methylation
epigenetic age
- real age
- real age
automated ML
NPDR
epigenetic age
NPDR
(regularized NPDR)
~ genetic variants
epigenetic age
Dimensions and stages of aging
Aim 3
Aim 2
Aim 2 + 3
select CpG sites
time
automated ML
brain age
brain age
Aim 1
\(allele_i \) carrier
\(allele_i \) non-carrier
time
composite \(\Delta\) age
Application: BrainAGE
simulation, correction, ibuprofen
RNASeq
