Identifying Recurrent Enhancer Mutations in Cancer

Leo Brueggeman

Kai Tan Lab

550 cancer patients

120 cancer patients (e.g. breast cancer)

Significant enhancers:

Approach B Results

* Red indicates significance

Pan-Cancer and Disease Specific Approach

52 Recurrent Enhancer Mutations Identified

Brain

Breast

T cell

Liver

B cell

Lung

Enhancers

Acknowledgements:

Kai Tan & Lab

Iowa MSTP