Research Object Composer

Stian Soiland-Reyes, Finn Bacall, Carole Goble

eScience lab, The University of Manchester

Internal meeting DataSTAGE Seven Bridges

2019-06-28

Findable

Accessible

Interoperable

Reusable

F1. (meta)data are assigned a globally unique and persistent identifier

 

F2. data are described with rich metadata (defined by R1 below)

 

F3. metadata clearly and explicitly include the identifier of the data it describes

 

F4. (meta)data are registered or indexed in a searchable resource

 

To be Findable:

A1. (meta)data are retrievable by their identifier using a
    standardized communications protocol
 

  A1.1 the protocol is open, free, and universally implementable


  A1.2 the protocol allows for an authentication and authorization
           procedure, where necessary

 

A2. metadata are accessible, even when the data are no longer available

To be Accessible:

I1. (meta)data use a formal, accessible, shared, and
    broadly applicable language for knowledge representation.

 

I2. (meta)data use vocabularies that follow FAIR principles

 

I3. (meta)data include qualified references to other (meta)data

To be Interoperable:

R1. meta(data) are richly described with a plurality of
    accurate and relevant attributes

 

  R1.1. (meta)data are released with a clear and accessible data usage license
 

  R1.2. (meta)data are associated with detailed provenance

 

  R1.3. (meta)data meet domain-relevant community standards

To be Reusable:

https://doi.org/10.1038/d41586-019-01307-2

They ride with what I refer to as the four horsemen of the reproducibility apocalypse:
  1. Publication bias
  2. Low statistical power
  3. P-value hacking
  4. HARKing (hypothesizing after results are known)

 

 

State of art in reproducibility

Data availability:

Domain-specific databases

CSV

FTP

Reproducibility?

Attribution

A Research Object bundles and relates digital resources of a scientific experiment or investigation:

 

Data used and results produced in experimental study

Methods employed to produce and analyse that data

Provenance and settings for the experiments

People involved in the investigation

Annotations about these resources, to improve understanding and interpretation

Research Object

id:        doi:10.15490/seek.1.investigation.56
createdOn: 2015-07-10T16:46:00Z
createdBy: http://orcid.org/0000-0001-9842-9718

aggregates:
 - id:         data/sequence/specimen5.bam
   conformsTo: http://gemrb.org/iesdp/file_formats/ie_formats/bam_v1.htm

 - id:         http://example.com/blog/about-specimen5
   authoredBy: http://orcid.org/0000-0001-7066-3350

 - id:         http://www.myexperiment.org/workflows/3355
   history:    provenance/workflow-evolution.ttl

annotations:
 - about:       data/sequence/specimen5.bam
   content:     annotations/specimen5-properties.jsonld
   createdBy:   http://orcid.org/0000-0001-7066-3350

 - about:       data/sequence/specimen5.bam
   content:     http://example.com/blog/about-specimen5
   motivatedBy: oa:questioning

Research Object manifest

(simplified)

Reuse standards:
OAI-ORE, BagIt, W3C JSON-LD, PROV, Web Annotation Model

metadata/manifest.json
data/sequence/specimen5.bam
provenance/workflow-evolution.ttl
http://example.com/blog/about-specimen5
http://www.myexperiment.org/workflows/335

http://orcid.org/0000-0001-7066-3350
http://gemrb.org/iesdb/
   file_formats_ie_formats_bam_v1.html

https://osf.io/h59uh/

doi:10.1101/191783

 http://biocomputeobject.org/

P2791 draft

--> JSON Schema

How can we capture the methods?

cwlVersion: v1.0
class: Workflow
inputs:
  inp: File
  ex: string

outputs:
  classout:
    type: File
    outputSource: compile/classfile

steps:
  untar:
    run: tar-param.cwl
    in:
      tarfile: inp
      extractfile: ex
    out: [example_out]

  compile:
    run: arguments.cwl
    in:
      src: untar/example_out
    out: [classfile]
{
  "@context" : [ "https://w3id.org/bundle/context" ],
  "id" : "/",
  "manifest" : [ "manifest.json" ],
  "createdOn" : "2017-08-24T10:57:46.325Z",
  "createdBy" : {
    "uri" : "https://view.commonwl.org",
    "name" : "Common Workflow Language Viewer"
  },
  "authoredBy" : [ {
    "uri" : "mailto:peter.amstutz@curoverse.com",
    "name" : "Peter Amstutz"
  }, {
    "uri" : "mailto:luka.stojanovic@sbgenomics.com",
    "name" : "Luka Stojanovic"
  }, {
    "uri" : "mailto:crusoe@ucdavis.edu",
    "name" : "Michael R. Crusoe"
  }, {
    "uri" : "mailto:porter@porter.st",
    "name" : "Andrey Kartashov"
  }, {
    "uri" : "mailto:janko.simonovic@sbgenomics.com",
    "name" : "Janko Simonovic"
  } ],
  "retrievedFrom" : "https://github.com/common-workflow-language/workflows/blob/lobstr-v1/workflows/lobSTR/",
  "retrievedOn" : "2017-08-24T10:57:46.325Z",
  "retrievedBy" : {
    "uri" : "https://view.commonwl.org",
    "name" : "Common Workflow Language Viewer"
  },
  "history" : [ "http:/git2prov.org/git2prov?giturl=https:/github.com/common-workflow-language/workflows.git&serialization=PROV-JSON" ],
  "aggregates" : [ {
    "uri" : "/workflow/tmp_2.fq",
    "mediatype" : "application/octet-stream",
    "createdOn" : "2017-08-24T10:57:46.923Z",
    "authoredBy" : [ {
      "uri" : "mailto:peter.amstutz@curoverse.com",
      "name" : "Peter Amstutz"
    } ],
    "retrievedFrom" : "https://raw.githubusercontent.com/common-workflow-language/workflows/lobstr-v1/workflows/lobSTR/tmp_2.fq",
    "retrievedBy" : {
      "uri" : "https://view.commonwl.org",
      "name" : "Common Workflow Language Viewer"
    },
    "bundledAs" : {
      "uri" : "urn:uuid:61579f3e-63e6-49c2-b780-f67b2df461b7",
      "folder" : "/workflow/"
    }
  }, {
    "uri" : "/workflow/lobSTR-demo.json",
    "mediatype" : "application/json",
    "createdOn" : "2017-08-24T10:57:47.216Z",
    "authoredBy" : [ {
      "uri" : "mailto:peter.amstutz@curoverse.com",
      "name" : "Peter Amstutz"
    } ],
    "retrievedFrom" : "https://raw.githubusercontent.com/common-workflow-language/workflows/lobstr-v1/workflows/lobSTR/lobSTR-demo.json",
    "retrievedBy" : {
      "uri" : "https://view.commonwl.org",
      "name" : "Common Workflow Language Viewer"
    },
    "bundledAs" : {
      "uri" : "urn:uuid:973caa0e-f3bd-45e8-8d29-70123bc8715a",
      "folder" : "/workflow/"
    }
  }, {
    "uri" : "/workflow/models/illumina_v3.pcrfree.stuttermodel",
    "mediatype" : "application/octet-stream",
    "createdOn" : "2017-08-24T10:57:47.239Z",
    "authoredBy" : [ {
      "uri" : "mailto:peter.amstutz@curoverse.com",
      "name" : "Peter Amstutz"
    } ],
    "retrievedFrom" : "https://raw.githubusercontent.com/common-workflow-language/workflows/lobstr-v1/workflows/lobSTR/models/illumina_v3.pcrfree.stuttermodel",
    "retrievedBy" : {
      "uri" : "https://view.commonwl.org",
      "name" : "Common Workflow Language Viewer"
    },
    "bundledAs" : {
      "uri" : "urn:uuid:62bbcbea-f34f-463f-990d-6148f8ed5e5c",
      "folder" : "/workflow/models/"
    }
  }, {
    "uri" : "/workflow/models/illumina_v3.pcrfree.stepmodel",
    "mediatype" : "application/octet-stream",
    "createdOn" : "2017-08-24T10:57:47.266Z",
    "authoredBy" : [ {
      "uri" : "mailto:peter.amstutz@curoverse.com",
      "name" : "Peter Amstutz"
    } ],
    "retrievedFrom" : "https://raw.githubusercontent.com/common-workflow-language/workflows/lobstr-v1/workflows/lobSTR/models/illumina_v3.pcrfree.stepmodel",
    "retrievedBy" : {
      "uri" : "https://view.commonwl.org",
      "name" : "Common Workflow Language Viewer"
    },
    "bundledAs" : {
      "uri" : "urn:uuid:03439ae7-cd94-42a3-b5fe-40bfff6882d8",
      "folder" : "/workflow/models/"
    }
  }, {
    "uri" : "/workflow/samtools-sort.cwl",
    "mediatype" : "text/x-yaml",
    "createdOn" : "2017-08-24T10:57:47.269Z",
    "authoredBy" : [ {
      "uri" : "mailto:luka.stojanovic@sbgenomics.com",
      "name" : "Luka Stojanovic"
    }, {
      "uri" : "mailto:crusoe@ucdavis.edu",
      "name" : "Michael R. Crusoe"
    }, {
      "uri" : "mailto:porter@porter.st",
      "name" : "Andrey Kartashov"
    }, {
      "uri" : "mailto:peter.amstutz@curoverse.com",
      "name" : "Peter Amstutz"
    } ],
    "retrievedFrom" : "https://raw.githubusercontent.com/common-workflow-language/workflows/lobstr-v1/workflows/lobSTR/samtools-sort.cwl",
    "retrievedBy" : {
      "uri" : "https://view.commonwl.org",
      "name" : "Common Workflow Language Viewer"
    },
    "conformsTo" : "https://w3id.org/cwl/v1.0",
    "bundledAs" : {
      "uri" : "urn:uuid:2dc07859-efc2-4945-a95f-ba7815b68d07",
      "folder" : "/workflow/"
    }
  }, {
    "uri" : "/workflow/lobSTR-workflow.cwl",
    "mediatype" : "text/x-yaml",
    "createdOn" : "2017-08-24T10:57:47.42Z",
    "authoredBy" : [ {
      "uri" : "mailto:luka.stojanovic@sbgenomics.com",
      "name" : "Luka Stojanovic"
    }, {
      "uri" : "mailto:crusoe@ucdavis.edu",
      "name" : "Michael R. Crusoe"
    }, {
      "uri" : "mailto:peter.amstutz@curoverse.com",
      "name" : "Peter Amstutz"
    } ],
    "retrievedFrom" : "https://raw.githubusercontent.com/common-workflow-language/workflows/lobstr-v1/workflows/lobSTR/lobSTR-workflow.cwl",
    "retrievedBy" : {
      "uri" : "https://view.commonwl.org",
      "name" : "Common Workflow Language Viewer"
    },
    "conformsTo" : "https://w3id.org/cwl/v1.0",
    "bundledAs" : {
      "uri" : "urn:uuid:58bc1895-3460-46d6-91d7-fa1718d09631",
      "folder" : "/workflow/"
    }
  }, {
    "uri" : "/workflow/lobSTR-arvados-demo.json",
    "mediatype" : "application/json",
    "createdOn" : "2017-08-24T10:57:47.453Z",
    "authoredBy" : [ {
      "uri" : "mailto:peter.amstutz@curoverse.com",
      "name" : "Peter Amstutz"
    } ],
    "retrievedFrom" : "https://raw.githubusercontent.com/common-workflow-language/workflows/lobstr-v1/workflows/lobSTR/lobSTR-arvados-demo.json",
    "retrievedBy" : {
      "uri" : "https://view.commonwl.org",
      "name" : "Common Workflow Language Viewer"
    },
    "bundledAs" : {
      "uri" : "urn:uuid:30c683bc-69fb-4d93-8dad-65b663783af5",
      "folder" : "/workflow/"
    }
  }, {
    "uri" : "/workflow/samtools-index.cwl",
    "mediatype" : "text/x-yaml",
    "createdOn" : "2017-08-24T10:57:47.458Z",
    "authoredBy" : [ {
      "uri" : "mailto:luka.stojanovic@sbgenomics.com",
      "name" : "Luka Stojanovic"
    }, {
      "uri" : "mailto:crusoe@ucdavis.edu",
      "name" : "Michael R. Crusoe"
    }, {
      "uri" : "mailto:porter@porter.st",
      "name" : "Andrey Kartashov"
    }, {
      "uri" : "mailto:peter.amstutz@curoverse.com",
      "name" : "Peter Amstutz"
    } ],
    "retrievedFrom" : "https://raw.githubusercontent.com/common-workflow-language/workflows/lobstr-v1/workflows/lobSTR/samtools-index.cwl",
    "retrievedBy" : {
      "uri" : "https://view.commonwl.org",
      "name" : "Common Workflow Language Viewer"
    },
    "conformsTo" : "https://w3id.org/cwl/v1.0",
    "bundledAs" : {
      "uri" : "urn:uuid:8235d3f8-6927-4f73-b160-8521838a1cbb",
      "folder" : "/workflow/"
    }
  }, {
    "uri" : "/workflow/lobSTR-tool.cwl",
    "mediatype" : "text/x-yaml",
    "createdOn" : "2017-08-24T10:57:47.476Z",
    "authoredBy" : [ {
      "uri" : "mailto:luka.stojanovic@sbgenomics.com",
      "name" : "Luka Stojanovic"
    }, {
      "uri" : "mailto:crusoe@ucdavis.edu",
      "name" : "Michael R. Crusoe"
    }, {
      "uri" : "mailto:peter.amstutz@curoverse.com",
      "name" : "Peter Amstutz"
    } ],
    "retrievedFrom" : "https://raw.githubusercontent.com/common-workflow-language/workflows/lobstr-v1/workflows/lobSTR/lobSTR-tool.cwl",
    "retrievedBy" : {
      "uri" : "https://view.commonwl.org",
      "name" : "Common Workflow Language Viewer"
    },
    "conformsTo" : "https://w3id.org/cwl/v1.0",
    "bundledAs" : {
      "uri" : "urn:uuid:7fa6fbe4-1fc5-4cb5-9c1a-56b96c5f7aaf",
      "folder" : "/workflow/"
    }
  }, {
    "uri" : "/workflow/allelotype.cwl",
    "mediatype" : "text/x-yaml",
    "createdOn" : "2017-08-24T10:57:47.537Z",
    "authoredBy" : [ {
      "uri" : "mailto:luka.stojanovic@sbgenomics.com",
      "name" : "Luka Stojanovic"
    }, {
      "uri" : "mailto:janko.simonovic@sbgenomics.com",
      "name" : "Janko Simonovic"
    }, {
      "uri" : "mailto:crusoe@ucdavis.edu",
      "name" : "Michael R. Crusoe"
    }, {
      "uri" : "mailto:peter.amstutz@curoverse.com",
      "name" : "Peter Amstutz"
    } ],
    "retrievedFrom" : "https://raw.githubusercontent.com/common-workflow-language/workflows/lobstr-v1/workflows/lobSTR/allelotype.cwl",
    "retrievedBy" : {
      "uri" : "https://view.commonwl.org",
      "name" : "Common Workflow Language Viewer"
    },
    "conformsTo" : "https://w3id.org/cwl/v1.0",
    "bundledAs" : {
      "uri" : "urn:uuid:3706bd2f-e53f-431d-b32a-deb661d9b292",
      "folder" : "/workflow/"
    }
  }, {
    "uri" : "/workflow/README",
    "mediatype" : "application/octet-stream",
    "createdOn" : "2017-08-24T10:57:47.555Z",
    "authoredBy" : [ {
      "uri" : "mailto:crusoe@ucdavis.edu",
      "name" : "Michael R. Crusoe"
    }, {
      "uri" : "mailto:peter.amstutz@curoverse.com",
      "name" : "Peter Amstutz"
    } ],
    "retrievedFrom" : "https://raw.githubusercontent.com/common-workflow-language/workflows/lobstr-v1/workflows/lobSTR/README",
    "retrievedBy" : {
      "uri" : "https://view.commonwl.org",
      "name" : "Common Workflow Language Viewer"
    },
    "bundledAs" : {
      "uri" : "urn:uuid:ed54c4d6-c585-4dc9-b7bc-0cf299e20b91",
      "folder" : "/workflow/"
    }
  }, {
    "uri" : "/workflow/tmp_1.fq",
    "mediatype" : "application/octet-stream",
    "createdOn" : "2017-08-24T10:57:47.738Z",
    "authoredBy" : [ {
      "uri" : "mailto:peter.amstutz@curoverse.com",
      "name" : "Peter Amstutz"
    } ],
    "retrievedFrom" : "https://raw.githubusercontent.com/common-workflow-language/workflows/lobstr-v1/workflows/lobSTR/tmp_1.fq",
    "retrievedBy" : {
      "uri" : "https://view.commonwl.org",
      "name" : "Common Workflow Language Viewer"
    },
    "bundledAs" : {
      "uri" : "urn:uuid:5d431f81-ad0b-4acf-903a-9d5aa03b04df",
      "folder" : "/workflow/"
    }
  }, {
    "uri" : "/visualisation.png",
    "mediatype" : "image/png",
    "createdOn" : "2017-08-24T10:57:47.801Z",
    "retrievedFrom" : "https://view.commonwl.org/graph/png/github.com/common-workflow-language/workflows/blob/lobstr-v1/workflows/lobSTR/lobSTR-workflow.cwl",
    "bundledAs" : {
      "uri" : "urn:uuid:ff9ace37-e76c-49f8-8d36-60f11ff6d257",
      "folder" : "/"
    }
  }, {
    "uri" : "/visualisation.svg",
    "mediatype" : "image/svg+xml",
    "createdOn" : "2017-08-24T10:57:47.821Z",
    "retrievedFrom" : "https://view.commonwl.org/graph/svg/github.com/common-workflow-language/workflows/blob/lobstr-v1/workflows/lobSTR/lobSTR-workflow.cwl",
    "bundledAs" : {
      "uri" : "urn:uuid:a6cfb437-8818-4ab2-9081-efc74c5109e8",
      "folder" : "/"
    }
  } ],
  "annotations" : [ {
    "uri" : "urn:uuid:9f602fff-b280-41c5-9590-ab95a49c85ad",
    "about" : "/",
    "content" : "annotations/merged.cwl"
  }, {
    "uri" : "urn:uuid:0ce4b727-ff61-4534-9afb-e3d676d2782d",
    "about" : "/",
    "content" : "annotations/workflow.ttl"
  } ]
}
#!/usr/bin/env cwl-runner
cwlVersion: v1.0
class: Workflow

label: "Hello World"
doc: "Outputs a message using echo"

inputs: []

outputs:
  response:
    outputSource: step0/response
    type: File

steps:
  step0:
    run:
      class: CommandLineTool
      inputs:
        message:
          type: string
          doc: "The message to print"
          default: "Hello World"
          inputBinding:
            position: 1
      baseCommand: echo
      stdout: response.txt
      outputs:
        response:
          type: stdout
    in: []
    out: [response]

Who is using Research Objects?

Research Object Composer

Demo

..extra slides

2019-06-28 Research Object Composer

By Stian Soiland-Reyes

2019-06-28 Research Object Composer

Presented at DataSTAGE Seven Bridges internal meeting 2019-06-28

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