Ishanu Chattopadhyay PRO
ML Data Science Biomedicine Social Science Faculty
Ishanu Chattopadhyay
Asst Professsor
ishanu@uchicago.edu
research@paraknowledge.ai
Zero-burden Screening for IPF
via
The Paraknowledge API
Dmytro Onishchenko
UChicago
[
{
"patient_id": "P000038",
"sex": "F",
"birth_date": "01-01-2006",
"DX_record": [
{"date": "07-31-2006", "code": "Z38.00"},
{"date": "08-07-2006", "code": "P59.9"},
{"date": "08-29-2016", "code": "J01.90"},
{"date": "09-10-2016", "code": "J01.90"},
{"date": "11-14-2016", "code": "J01.91"}
],
"RX_record": [
{"date": "10-29-2011", "code": "rxLDA017"},
{"date": "05-16-2015", "code": "rxIDG004"},
{"date": "08-08-2015", "code": "rxIDG004"},
{"date": "06-04-2016", "code": "rxIDD013"}
],
"PROC_record": [
{"date": "02-05-2007", "code": "90723"},
{"date": "11-05-2007", "code": "J1100"}
]
}
]
{
"predictions": [
{
"error_code": "",
"patient_id": "P000012",
"predicted_risk": 0.005794344620009157,
"probability": 0.8253881317184486
}
],
"target": "TARGET"
}
Data In
Data Out
The Paraknowledge API
curl -X POST -H "Content-Type: application/json" -d '[{"patient_id": "P28109965201", "sex": "M", "age": 89, "fips": "35644", "DX_record": [{"date": "12-16-2011", "code": "R09.02"}, {"date": "12-30-2011", "code": "H04.129"}, {"date": "12-30-2011", "code": "H02.109"}], "RX_record": [], "PROC_record": [{"date": "09-28-2012", "code": "71100"}]}]' "https://us-central1-pkcsaas-01.cloudfunctions.net/zcor_predict?target=IPF&api_key=7eea9f70d79c408f2b69847d911303c"
Current Targets
IPF
ILD
ADRD
CKD
CKD_SEVERE
MELANOMA
CANCER_PANCREAS
CANCER_UTERUS
SISA
Cohort Selection and Risk Analysis Testbed
Baseline prevalence of IPF in ILD patients
~25%
ZCoR PPV: 60% @ 50% sensitivity
1310 positive patients from 2183 flags
screen failure:
~70% \(\rightarrow\) 40%
Selection comparison against baseline of 2+ ILD risk factors
baseline prevalence: ~2%
projected screen failure:
~98% baseline \(\rightarrow\) 45%
The Paraknowledge API
curl -X POST -H "Content-Type: application/json" -d '[{"patient_id": "P28109965201", "sex": "M", "age": 89, "fips": "35644", "DX_record": [{"date": "12-16-2011", "code": "R09.02"}, {"date": "12-30-2011", "code": "H04.129"}, {"date": "12-30-2011", "code": "H02.109"}], "RX_record": [], "PROC_record": [{"date": "09-28-2012", "code": "71100"}]}]' "https://us-central1-pkcsaas-01.cloudfunctions.net/zcor_predict?target=IPF&api_key=7eea9f70d79c408f2b69847d911303c"
Current Targets
IPF
ILD
ADRD
CKD
CKD_SEVERE
MELANOMA
CANCER_PANCREAS
CANCER_UTERUS
SISA
Security Compliance
Patient Journeys for IPF: Tracking increasing Risk Over Time
Upto 4 year "signal" resolution
patient journey
Other Examples
decreases risk
increases risk
Risk decreases sometimes
new codes change trajectory as they are revealed
By Ishanu Chattopadhyay
paraknowledge
ML Data Science Biomedicine Social Science Faculty