Allergy in pets

  genetically pre-disposed
condition of hypersensitivity
to common and harmless
substances

Allergy

Outdoor
Seasonal

Indoor
Non-seasonal

Breeds at
higher risk

Allergen-specific
immunotherapy
is the only causal
treatment

Allergen
avoidence

Symptomatic
medication
side effects

Food allergy

Incidence between 10-25% of
dogs with allergic skin disease
or 1/3 of dogs with AD

Stronger incidence in dogs
under 1 year or above 6 years

Most common allergens:
beef, chicken, egg, milk,
wheat, soy and corn

Allergy in horses

  genetically pre-disposed
condition of hypersensitivity
to common and harmless
substances

Allergy

Specific panel
for horses

1 monoclonal
antibody derived
from recombinant
horse IgE

30 most relevant
indoor and
outdoor allergens
including insects

High specificity
and sensitivity

Fast and
reliable results

Easy to interpret result, comes with clear advice
and support

no cross
reactivity with IgG

Polyclonal antibodies:
recognise multiple epitopes on an antigen;
higher sensitivity;
are robust and more stable;
have high batch-to-batch variability;
likely to cross-react (IgE/IgG)

Monoclonal antibodies:
recognise one epitope on an antigen;
deliver a high degree of reproductibility;
high specificity (single epitope);
Reduced probability of cross reactivity;
more recent technology
 

rIgE derived from Mon. Cocktail:
1 relevant antibody identified and used;
virtually no chance of cross reactivity with IgG;
recombinant IgE as source of antibodies;
fewer steps in testing: less chance for error;
latest technology; high sensitvity/specificity

Monoclonal Cocktail:
best of Polyclonal and Monoclonal combined;
recognise 3x available epitopes;
higher sensitivity;
higher specificity;
ongoing production of identical antibodies

More than
80 allergens
available

Fast result,
in 15-20 minutes

 Concentrations
based on
determination of
threshold values
for reliable result

! Medication that
may affect the
result needs to be
discontinued

Animal becomes
less sensitive or
even insensitive
to allergens

Only causal
treatment for
atopic dogs, cats
and horses

Only licensed ASIT
in Europe*:
product of choice
 

Safe for long-term
treatment:
virtually no
side effects
 

Taylor made for
each individual
patient

®

Dogs

Cats

Horses

75%

70%

84%

This is Diesel
6x Dutch Champion
3 World Championships
2 International
3* Competitions

Don’t let
allergies stop
them from being
champions!

Before

Before

 
Serum Test

Most relevant indoor and
outdoor allergens

Specially developed
for dogs, cats and horses

High specificity
and sensitivity

Fast and
reliable results

Easy to interpret result, comes with clear advice and support

Next-generation CCD blockers + no cross reactivity with IgG

Specific panel
for dogs and cats

32 allergens
including Malassezia

3 monoclonal
antibodies derived from
recombinant dog IgE

Specific panel
for horses

32 allergens
including insects

1 monoclonal
antibody derived from
recombinant horse IgE

Employs
NEXT-generation
CCD blockers

Polyclonal antibodies:
recognise multiple epitopes on an antigen;
higher sensitivity;
are robust and more stable;
have high batch-to-batch variability;
likely to cross-react (IgE/IgG)

Monoclonal antibodies:
recognise one epitope on an antigen;
deliver a high degree of reproductibility;
high specificity (single epitope);
Reduced probability of cross reactivity;
more recent technology
 

rIgE derived from Mon. Cocktail:
3 most relevant antibodies identified and used;
virtually no chance of cross reactivity with IgG;
recombinant IgE as source of antibodies;
fewer steps in testing: less chance for error;
latest technology; high sensitvity/specificity

Monoclonal Cocktail:
best of Polyclonal and Monoclonal combined;
recognise 3x available epitopes;
higher sensitivity;
higher specificity;
ongoing production of identical antibodies

Based on high predictive
negative values
(Ø75% IgE and 84% IgG)

Helps selecting suitable
ingredients for an elimination diet
 

Measures IgE and IgG
for 20 ingredients
 

Comes with a food recommendation
list for commercial diets
 

Artuvetrin®
Skin Test

More than 80
allergens available

Fast result, in
10-20 minutes

 Concentrations
based on
determination of
threshold values
for reliable result

! Medication that
may affect the
result needs to be
discontinued

TIP

Fluorescein makes
the wheals stand out

Picture: Charlie Walker

When the negative
control is not 0

(negative control +
positive control) / 2 =

Example

Negative control = 6

Positive control = 14
 

(6 + 14) / 2 = 10 mm

All allergens equal
or higher than
10 mm is positive

Artuvetrin®
Therapy

Animal becomes
less sensitive or
even insensitive
to allergens

Only causal
treatment for
atopic dogs, cats
and horses

Only licensed ASIT
in Europe*:
product of choice
 

Safe for long-term
treatment:
virtually no
side effects
 

Taylor made for
each individual
patient

®

Dogs

Cats

Horses

75%

70%

84%

 Continue a monthly injection interval

1 ml every 4 weeks is standard, but some cases may have
better results  with
0.5 ml every 2 weeks
 

Life-long treatment

Increased
symptoms directly
after the injection
which decrease
after 1-2 days

Increased
symptoms 1-2 weeks
before next
injection

Lower the dose
for 1-2 injections
i.e. 0.8 ml

Shorten interval
0.5 ml / 2 weeks
0.8 ml / 3 weeks

A clinically
relevant allergen:

1. is tested positive or
borderline AND

2. is present in the animals
environment AND

3. has a clear relationship
with clinical history
 

Composing

Up to 8 allergens and/or mixtures can be included

If only 1 vial can be produced due to costs or compliance we can:

Replace an individual allergen for an allergen mixture

Exclude an individual allergen due to cross
reactivity

Exclude an individual allergen based on
clinical relevance

A pollen mixture
contains several
allergens (grasses,
weeds, trees, moulds)

Immune system
recognises two
allergens as
structurally the same

1. mites
2. grasses
3. weeds
4. trees
5. other

This is Bob
Bob has recurring
otitis since the
age of 2

This is Pascal
Pruritus every winter
since he was a few
months old
 

Raising above
the itch threshold:

1. higher allergen exposure

2. secondary infection

3. skin irritation like
fleas, swimming, more or
less washing, etc.

Flare-up
 

Find and
prevent the
cause

Sometimes
symptomatic
medication is
sufficient

Vicious circle:
non-seasonal
symptoms
 

Sublingual
immuno-
therapy
 

Considered safe

Averse to needles
(pet or pet parent)

A daily routine
is easier

Easy administration
once daily

Up to 12
allergens per vial

Safe: minimum
side effects

Pet's Relief®
Products

Liquid

enhances EPA and
DHA absorption
compared to capsules
 

Omega 3

Maintains natural skin barrier

Promotes skin repair

Helps to control excessive skin inflammation

Supports neutralisation of
free-radicals (antioxidant)

plays important role on immune system regulation, wound healing and
keratinisation
 

anti-inflammatory agent, joint/muscle pain, oxidative stress and antioxidant
capacity

antioxidants,
low levels of plasma
vitamine E found in CAD

epithelial homeostasis
and keratinisation,
essential for vitamin A- responsive dermatitis

ZINC

MSM

Vit. E and C

Vitamin A

Once a day
Mixed with food or
directly into the mouth

Minimum administration
6 weeks and ideally on
an ongoing basis

200 ml bottle
Comes with a syringe and
does not leak: Sealsafe system
 

SKIN CREAM WITH
ZINC OXIDE + 9 HERBAL EXTRACTS

Centella asiatica, Echinacea purpurea, Calendula officinalis,
Hamamelis virgiana, Melaleuca viridiflora, Thuja occidentalis,
Lavendula angustifolia, Salvia lavandulifolia, Arnica montana

ZINK
Cell membrane repair
Cell proliferation
Growth and immune system function

ECHINACEA PURPUREA
Stimulates immune responses
Stimulates fibroblasts cell growth and wound healing process

CALENDULA OFFICINALIS
Antiseptic
Anti-inflammatory and
analgesic properties
Contributes in easing pain

CENTELLA ASIATICA
Inhibits inflammation
Reduces wound oxidative stress
Affects cellular growth and proliferation in injured tissues

HAMAMELIS VIRGINIANA
Strengthens vein elasticity
Stimulates micro-circulation of new-formed tissue
Prevents scar tissue
 

THUJA OCCIDENTALIS
Antiviral
Anti-inflammatory
Antibacterial properties

SALVIA LAVANDULIFOLIA
Antiseptic
Analgesic
Sedative and anesthetic activities
 

MELALEUCA VIRIDIFLORA
It is used for its
anti-microbial effect without irritating sensitive tissues

LAVANDULA ANGUSTIFOLIA
Accelerates wound healing
Formation of granulation tissue
Tissue remodeling
Wound contraction (shrinking)

ARNICA MONTANA
Can be used for sprains, dislocations and rheumatic pain
Anti-inflammatory
Mild analgesic effect
 

Proven efficacy

All components are recognised by studies for their properties

Versatility

Can be applied to any type of superficial injury

Compatibility

Can be used on its own or along side other products

50 and 150 ml bottle

Airless dispenser for easy and hygenic application

Apply at least twice a day
(or with bandage once a day):

1. Clean the injured tissue and skin
(gently wash off crusts first)

2. Apply enough to create a thin protective layer of cream

Hypromellose, poly (vinyl alcohol), citric acid, isopropyl myristate, benzyl benzoate, colloidal silica.

Loyalty & Care
program

Free educational
programs

Online news and developments

Newsletter
Website
 

Our specialised staff
are happy to help you
with a case
 

Reminder service
for your practice
Personalised
emails
 

Reminder service
for your clients
App and
Web-reminder

Lunch & Learn

Webinars

DermaTalks

In house days

My allergic pet
sessions

Allergy Treatment APP

Pet owners can:
Receive a notification when it is time for treatment
Keep track of doses given
Receive a reminder when a follow-up-treatment needs to be ordered
 

Online
ordering

Order your treatment or serum
test quick and easy online

Visit artuvet.com and click ‘online ordering’.

At your personal dashboard you can request serum tests, order treatment and download brochures.

Reorders can be done easily
in your order history.

Virtual
Vet Derms

Tricky case?

We can help!

Tricky case?

We can help!

We can help you:

Design a diagnostic protocol

Put together treatment regimes specially for each individual animal

Virtual Vet Derms
offers a helping hand to avoid all the pitfalls on the diagnostic and therapeutic pathway

We can help you:

Manage flare ups

Bring cases under control when things don't go completely to plan