Is my horse allergic?

  genetically pre-
disposed condition of hypersensitivity to
common and harmless
substances

Allergy

Sweet Itch 

Summer Dermatitis

Atopy - envirnomental allergens

Common symptoms

Specific panel
for horses

1 monoclonal
antibody derived
from recombinant
horse IgE

32 most relevant
indoor and
outdoor allergens
including insects

High specificity
and sensitivity

Fast and
reliable results

Easy to interpret result, comes with clear advice and support

No cross
reactivity with IgG

Polyclonal antibodies:
recognise multiple epitopes on an antigen;
higher sensitivity;
are robust and more stable;
have high batch-to-batch variability;
likely to cross-react (IgE/IgG)

Monoclonal antibodies:
recognise one epitope on an antigen;
deliver a high degree of reproductibility;
high specificity (single epitope);
Reduced probability of cross reactivity;
more recent technology
 

rIgE derived from Mon. Cocktail:
1 most relevant antibody identified and used;
virtually no chance of cross reactivity with IgG;
recombinant IgE as source of antibodies;
fewer steps in testing: less chance for error;
latest technology; high sensitvity/specificity

Monoclonal Cocktail:
best of Polyclonal and Monoclonal combined;
recognise 3x available epitopes;
higher sensitivity;
higher specificity;
ongoing production of identical antibodies

Why the type of test is important?

More than
80 allergens
available

Fast result,
in 10-20 minutes

 Concentrations
based on
determination of
threshold values
for reliable result

! Medication that may affect the result needs to be discontinued

Artuvetrin® Skin Test

Animal becomes less
sensitive or even
insensitive to allergens

Only causal treatment
for atopic dogs, cats
and horses

Only licensed ASIT
in Europe*:
product of choice
 

Safe for long-term
treatment: virtually no
side effects

Tailor made for
each individual
patient

®

Dogs

Cats

Horses

75%

70%

84%

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_____

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Artuvetrin® Therapy

Highest category
of evidence and strength of recommendation

The international Task Force on Canine Atopic Dermatitis has concluded that allergen-specific immunotherapy has the highest category of evidence (COE 1a) and the highest strength of recommendation (SOR A) for the treatment of atopic dermatitis.

 Continue a monthly
injection interval

1 ml every 4 weeks is
standard, but some cases
may have better results 
with 0.5 ml every 2 weeks

Life-long treatment

Artuvetrin® Therapy is the only licensed immunotherapy in Europe, therefore under the European veterinary medicine's regulations and cascade (directive 2004/28/EC),
the product of choice for horses

Why Artuvetrin® Therapy?

A clinically
relevant allergen:

1. is tested positive or
borderline AND

2. is present in the animals
environment AND

3. has a clear relationship
with clinical history

Composing

Up to 8 allergens and/or mixtures can be included

If only 1 vial can be produced due to costs or compliance we can:

Replace an
individual allergen for an allergen mixture

Exclude an individual allergen due to cross
reactivity

Exclude an individual allergen based on clinical relevance

A pollen mixture contains several allergens (grasses, weeds, trees, moulds)

Immune system
recognises two allergens
as structurally
the same

1. mites
2. grasses
3. weeds
4. trees
5. other

The multimodal approach

DERM-10

WOUND HEALING

Zinc Oxide
9 herbal extracts

ALLERGONE

ALLERGEN
NEUTRALISING SPRAY

House dust allergens
5 months protection

SKIN CREAM WITH
ZINC OXIDE + 9 HERBAL EXTRACTS

Centella asiatica, Echinacea purpurea, Calendula officinalis,
Hamamelis virgiana, Melaleuca viridiflora, Thuja occidentalis,
Lavendula angustifolia, Salvia lavandulifolia, Arnica montana

ZINC
Cell membrane repair
Cell proliferation
Growth and immune system function

ECHINACEA PURPUREA
Stimulates immune responses
Stimulates fibroblasts cell growth and wound healing process

CALENDULA OFFICINALIS
Antiseptic
Anti-inflammatory and
analgesic properties
Contributes in easing pain

CENTELLA ASIATICA
Inhibits inflammation
Reduces wound oxidative stress
Affects cellular growth and proliferation in injured tissues

HAMAMELIS VIRGINIANA
Strengthens vein elasticity
Stimulates micro-circulation of new-formed tissue
Prevents scar tissue
 

SALVIA LAVANDULIFOLIA
Antiseptic
Analgesic
Sedative and anesthetic activities
 

THUJA OCCIDENTALIS
Antiviral
Anti-inflammatory
Antibacterial properties

MELALEUCA VIRIDIFLORA
It is used for its
anti-microbial effect without irritating sensitive tissues

LAVANDULA ANGUSTIFOLIA
Accelerates wound healing
Formation of granulation tissue
Tissue remodeling
Wound contraction (shrinking)

ARNICA MONTANA
Can be used for sprains, dislocations and rheumatic pain
Anti-inflammatory
Mild analgesic effect
 

Proven efficacy

All components are recognised by studies for their properties

Versatility

Can be applied to any type of superficial injury

Compatibility

Can be used on its own or along side other products

50 and 150 ml bottle

Airless dispenser for easy and hygenic application

Apply at least twice a day
(or with bandage once a day):

1. Clean the injured tissue and skin
(gently wash off crusts first)

2. Apply enough to create a thin protective layer of cream

Hypromellose, poly (vinyl alcohol), citric acid, isopropyl myristate, benzyl benzoate, colloidal silica.

Other allergen avoidance measures

Insect Bite Hypersensitivity

House dust and storage mites

Reduce exposure to insects by moving horses away from standing water, manure piles, compost and cattle

Consider keeping the horse outside or restrict stabling

Stable the horse before dusk and until after dawn

Use fly sheets or masks sprayed with permethrin

Place box fans within the stall

House dust and storage mites

Minimalise dust in the barn and consider purchasing rubber mats to replace stall bedding

Wash blankets, saddle pads and leg bandages regularly with
60°C hot water

Use airtight containers to keep food tightly closed and store in a cool, dark and dry place

Reduce food stockpiles by buying smaller amounts. Max storage time should be less than 30 days

Wipe the face with a damp cloth after finishing a meal to remove food remains. Keep food buckets, bins and tubs clean

This is Diesel
6x Dutch Champion
3 World Championships
2 International
3* Competitions

Don’t let
allergies stop
them from being
champions!

Before

Before