Sickle Cell Anemia

By: Aliyah Ali, Brianna Bal, Pavela Bambekova, Brianna Bishop, Alejandro Braun, & Bobby Palmos

Introduction

Hemoglobin Structure

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Genetics

- Autosomal recessive genetic disorder

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Genetics

- HBB gene on p arm of chromosome 11 affected

- Codes for beta-hemoglobin subunits 

- On the sixth codon, the nucleotide thymine replaces adenine 

- This results in replacement of polar, negatively charged glutamic acid with non-polar valine

Genetics

- Normal beta-hemoglobin (HbA) is converted to abnormal beta-hemoglobin (HbS) 

- Sickle cell trait individual is heterozygous (HbAS)

- Sickle cell anemia is homozygous (HbSS)

- HbSC, HbSE, HbSO, and HbS beta-thalassemia are other forms of the sickle cell disease  

GeBioBiochemistry

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GeBioTreatment 

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Conclusion

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Works Cited

Nicholas H. Sickle Cell video citation: NHLBI. “Our Story: Living with and Managing Sickle Cell Disease.”

Online Video Clip. Youtube. Youtube, 2 Sep. 2011. Web. 13 Dec. 2014.

http://www.coloradosicklecellcenter.org/SickleCellTraitCourse/module1/WhatIsSickleCellTrait.htm

http://termlifeinsurancemales.com/life-insurance-with-health-risks/life-insurance-approval-with-sickle-cell-or-sickle-cell-anemia/

http://learn.genetics.utah.edu/content/disorders/singlegene/sicklecell/