T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
Thorsten R. Mempel, Sarah E. Henrickson & Ulrich H. von Andrian
Jenny Lu
Howard Li
ME728
7/11/2014
Nature. 2004 Jan 8; 427(6970):154-9.
Background
T-cell Migration in the Adaptive Immune SystemTwo Photon Imaging
Intravital Microscopy
Two Photon Imaging
Intravital Microscopy
T-cell migration
von Andrian UH, Mackay CR. T-cell function and migration. Two sides of the same coin. N Engl J Med. 2000 Oct 5;343(14):1020-34. Review.
Two-photon Imaging
Intravital Microscopy
Liou HL, Myers JT, Barkauskas DS, Huang AY. Intravital imaging of the mouse popliteal lymph node. J Vis Exp. 2012 Feb 8;(60). pii: 3720. doi: 10.3791/3720.
Figure 1
Figure 2: T-cell motility
Figure 3: TC/DC interactions
Discussion
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key findings
- technology and discovery
- setting the stage
Mempel et al, 2004, Curr. Opin. Imm.
Hendrickson et al, 2007, Curr. Opin. Imm.
movies!
T-cell priming by dendr
By Howard Li