Copy of Directed networks as a novel approach for improving the management of cardiac arrhythmias

Different websites are linked: form directed network

Search algorithm

What is the link with cardiac arrhythmia?

1/4 over the age of 40 develops cardiac arrhythmia

To understand what is a cardiac arrhythmia, first we need to understand how the heart works normally

Normal rhythm of about 60 beats/min (determined by SA node)

=> 100.000 beats per day

=> 3 000 000 000 in a lifetime!!!

How can this electrical wave go wrong?

When something goes wrong with these electrical waves: cardiac arrhythmia

1. Rotating electrical waves

electrical waves can rotate around an obstacle like a valve, scar tissue or the veins = anatomische reentry -> mexican wave!

When something goes wrong with these electrical waves: cardiac arrhythmia

1. Rotating electrical waves

Electrical waves can even rotate around itself!

This rotating wave act like a source and take over the normal rhythm of the sino atrial node

When something goes wrong with these electrical waves: cardiac arrhythmia

1. Rotating electrical waves

Focal sources give rise to electrical waves which spread centrifugal

if fast, they also take over the normal rhythm

When something goes wrong with these electrical waves: cardiac arrhythmia

2. Focal sources

How to treat an arrhythmia?

Ablation: creating scar (via burning) to interrupt the rotation path

1. Rotating electrical waves

Ablation: removing the focal source by burning it

2. Focal sources

Ablation is one of the most preveland procedures in electrophysiology

In electrophysiology there still exist no good algorithms to determine the location of cardiac arrhythmia

AT is a regular arrhythmia
Symptoms: palpitations, lichtheadedness, sweating, shortness of breath, chest pain
AT has a large incidence: 2.3/1000 people. Also ablation of atrial fibrillation can result in atrial tachycardia
Possible sources of AT

1. Rotating electrical waves:

around a piece of scar
around the veins
around the mitral valve ...
...

2. Focal source

Example: atrial tachycardia

Measurements give rise to a color map.

Needs to be interpreted manually: challenging and operator dependent.

Local activation time

Atrial tachycardia: current stategy

In electrophysiology there exist still no good algorithms to automatically detect these sources.
Therefore, we developed a novel methodology to determine these sources automatically: we describe the electrical propagation in the heart as a directed network:

Directed Graph(DG)-mapping

Here is our link to network theory and Google!

Network theory has many applications...

Brain

Facebook

Search algorithm

We can find these rotating electrical waves very easily, they are just the cycles in our network

But was not yet applied to the heart...

atrial tachycardia is a directed graph!

Demo-time!!!

OC4 - period 260 ms

We are currently adding additional features to our software, to increase the guidance for the electrophsyiologist

We set up a collaboration with AZ-sint Jan Bruges

Prof. Dr. Mattias Duytschaever

Prof. Dr. Sebastien Knecht

Dr. Jan De Pooter

30 cases after ablatie: DG-mapping 100% correct
51 real-time cases, but 30 complex.

1. DG-mapping: 74% correct:

2. Expert + latest system : 64% correct

3. Junior + latest system: 48% correct

Dr. Jan De Pooter

Dr. Teresa Strisciuglio

We can compete with the latest mapping systems which have 20 years of development!

Vandersickel et al, 2018

Van Nieuwenhuyse et al, in prep

We set up a collaboration with AZ-sint Jan Bruges

Prof. Dr. Mattias Duytschaever

Prof. Dr. Sebastien Knecht

Dr. Jan De Pooter

Dr. Teresa Strisciuglio

DG-mapping can automatically find the mechanism of an AT without manual interpretation of the colormap of the atrium

Operator independent and in some cases better than the operator: DG-mapping removes intuition, is thus very robust
Can limit the amount of scar
Added value for complex cases
Can be used for training of fellows
Faster: DG-mapping is instantaneous
We try limit entrainment mapping which is an extra technique usually performed

A patent is filed for this technology (PCT nov 2018)
In close contact with TechTransfer: David Aubert -> Business developer
Interest from companies: Boston Scientific and Philips
Goal: bring this technology to the patient!

Still room for improvement: +13%

Future: Atrial tachycardia

Test and improve DG-mapping on AT with new collaborations in multiple hospitals

MD. De Potter,

Aalst

Prof. Boyle,

Washington

MD. Derval, Bordeaux

AT

VT

VF

AF

DG-mapping

Future: Atrial tachycardia

New collaboration

Prof. Clayton, Sheffield

AT

VT

VF

AF

DG-mapping

Future: Ventricular Fibrillation

New collaboration (FWO-project)

Prof. MD. Zeppenfeld, Leiden

Prof. MD. Knecht, Bruges

AT

VT

VF

AF

DG-mapping

Future: Ventricular Tachycardia

AT

VT

VF

AF

New collaboration with

Prof. Saiz, Valencia

Continue collaboration

Prof. Duytschaever

Future: Atrial fibrillation

Atrial fibrillation (AF): most prevalent cardiac arrhythmia in the world, 6fold increase of stroke, leads to anxiety, depression, and reduced quality of life.
Ablation: has only 50% success rate!
Mechanism is heatedly debated
Is AF maintained by rotational electrical
waves?

Future: Atrial fibrillation

FIRM (Focal Impulse and Rotor Modulation) which works with a technique called phase mapping
In studies let by the inventors: very high successratio (90%)
FIRM is sold for 250 million dollar to Abbott
Independent research shows that FIRM does not work, only (50%) succesratio

Future: Atrial fibrillation

Phase mapping?

Kuklik et al, 2017, IEEE Trans Biomed Eng.:

``Great methodological care has to be taken before equating detected phase mapping with rotating waves and using phase mapping detection algorithms to guide catheter ablation of atrial fibrillation''

Future: Atrial fibrillation