Alternative ICA based denoise (sequential)

What is the best way to denoise the data after ICA?

  Regression based:

  1. Aggressive approach: nuisance regression using only the rejected components.

  2. Non aggressive (partial regression) approach: all the components are considered, but only the rejected components are regressed out of the data.

  3. Orthogonalised approach: the rejected components are orthogonalised with respect to the other components.


  4. 4D-based approach (similar to M/EEG): reconstruct volumes on noise, then subtract it from the original data.

\( Y = \) \(A\) \(+\) \(R\) \(+ n \)

  Multivariate:

Alternative ICA based denoise (sequential)

Effect of denoising approach is significant for slope (F(5,354)=177.6, p<0.001) and intercept (F(5,354)=225.7, p<0.001) of the linear regression model

DVARS vs FD

Group level, DVARS vs FD

Slope

Intercept

Alternative ICA based denoise (sequential)

Average % BOLD and DVARS across all trials

Aggressive denoise removes signal of interest

OC and E-02 denoise affects the signal of interest more than ICA denoise

Alternative ICA based denoise (sequential)

Lag reliability

CVR reliability

Notes on Denoising

By Stefano Moia