16 septembre 2016

MISSION

To offer an

automated pipeline to process diffusion neuroimaging data

  • Easy to use (to convert, to run the pipeline)
  • Well documented (English and French version)
    • http://unf-montreal.ca/toad/html/en/index.html
  • Web based QA

10 labs have used TOAD during its first year

  • Conversion
  • Analysis
  • QA
  • Visualization

Updates

- Works with Skyra scanner (soon with Prisma)

- Get a lot more information from dicom header saved in your config.cfg file

- Single command line -

dcm2toad unf-data.tar.gz

Config.cfg

[prefix]
b0_ap = b0_ap
anat = anat
dwi = dwi
grad = dwi
mag = mag
phase = phase

[correction]
echo_spacing = 0.689982557241
phase_enc_dir = 1
epi_factor = 96.0
echo_time_mag1 = 4.92
echo_time_mag2 = 7.38

[denoising]
number_array_coil = 4
[methodology]
manufacturer = SIEMENS
magneticfieldstrength = 3
mrmodel = TrioTim
t1_tr = 2300.0
t1_te = 2.98
t1_ti = 900.0
t1_flipangle = 9.0
t1_voxelsize = [1.0, 1.0, 1.0]
t1_matrixsize = [256, 256]
t1_numberslices = 176
t1_fov = 256.0
t1_studyuid = 1.3.12.2.1107.5....
dwi_tr = 9300.0
dwi_te = 94.0
dwi_flipangle = 90.0
dwi_voxelsize = [2.0, 2.0, 2.0]
dwi_matrixsize = [96, 96]
dwi_numberslices = 64
dwi_fov = 192.0
dwi_studyuid = 1.3.12.2.1107.5.2....
dwi_bvalue = 1000
dwi_numdirections = 64
dwi_patfactor = 1.0
intrasession = False

[prefix]
b0_ap = b0_ap
anat = anat
dwi = dwi
grad = dwi
mag = mag
phase = phase

[correction]
echo_spacing = 0.689982557241
phase_enc_dir = 1
epi_factor = 96.0
echo_time_mag1 = 4.92
echo_time_mag2 = 7.38

[denoising]
number_array_coil = 4

- Single command line -

toad .

In development

In development

More options

*

In development

More options

New task

New Tasks

- TractQuerier (Wassermann et al. 2016)

Dictionary

Atlas

Caudate.left |= 11
Caudate.right |= 50
Putamen.right |= 51
Pallidum.right |= 52
Hippocampus.right |= 53
Amygdala.right |= 54
Insula.right |= 55

Dictionary

Caudate.left |= 11
Caudate.right |= 50
Putamen.right |= 51
Pallidum.right |= 52
Hippocampus.right |= 53
Amygdala.right |= 54
Insula.right |= 55

Queries

cc_superiotemporal = 
       superiortemporal.left 
       and superiortemporal.right 
       not in subcortical.left
       not in subcortical.right
       not in cerebellum

- TractQuerier (Wassermann et al. 2016)

New Tasks

- TractFiltering (Cousineau et al 2016. ISMRM, Coté et al 2015. ISMRM)

New Tasks

- Tractometry (Cousineau et al 2016. ISMRM)

FA

NUFO

*

Metrics

  • Mean value per bundle
  • Mean value per point
  • Profile
  • Volume

 

For each step of the pipeline:

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REAL   LIFE

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REAL    LIFE

Real study with real subjects:

1 - Run dcm2toad

2 - Run toad

4 - Run Analysis

3 - Check QA

-----------------

REAL    LIFE

Real study with real subjects:

4 - Run Analysis

TBSS analysis (whole brain, skeleton)

Tractography analysis (bundle specific)

Be careful with interpretations

Need to learn how to write your own queries, dictionnary

Choose a different atlas or modify wmparc

There is more than 15-TractographyMrtrix output

-----------------

REAL  LIFE

Real study with real subjects:

4 - Run Tractography analysis

Need to learn how to run tractography

-----------------

REAL  LIFE

-current projects-

-----------------

REAL  LIFE

Project: Catherine Vien, Julien Doyon

FA

NUFO

-----------------

REAL  LIFE

Project: Catherine Vien, Julien Doyon

-----------------

REAL  LIFE

Project: Mariem Boukadi, Simona Brambati et Maxime Descoteaux

Le rôle de la régénération des fibres de matière blanche dans la récupération spontanée du langage dans l’aphasie post-AVC

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WHAT'S NEXT ?

-----------------

WHAT'S NEXT ?

  • New denoising methods
  • New reconstructions using multi-shells acquisitions
  • New tractography algorithms (Global tractography)
  • BIDS compatibility (Brain Imaging Data Structure)
  • ...

MERCI

http://unf-montreal.ca/toad/html/en/index.html

toadunf.criugm@gmail.com

TOAD_16_septembre_16

By Arnaud Boré