Intrinsic Capacity

Intrinsic Capacity

Retrospective Validation Timeline

Dementia

Target: Dementia (F00-F03, F05, F06.8) and degenerative diseases of the nervous system (G30-G32)

Dataset size:
Case: 78.1k, Control: 1.4M

Dementia

SHAP Values for Male True Positive patients

Progression from Rheumatoid Arthritis to ILD

Cohort - 50-85 years old, diagnosed with Rheumatoid Arthritis
(ICD10: M05-M06)

Target Condition - ILD (ICD10: J84.1, J84.89, J84.9)

Data Used - Diagnostic, Prescription, and Procedure records for 1-3 years leading to the time of screening

Problem 1 - Predict ILD Dx 1 year in advance

Males:
AUC 79.6% (74.2%, 85.1%)
Sensitivity 26.7% (18.3%, 35.2%)
Positive LR: 6.01 (3.65, 7.04)
Negative LR: 0.77 (0.86, 0.68)

Females:
AUC 79.4% (75.4%, 83.4%)
Sensitivity 27.3% (21.2%, 33.4%)
Positive LR: 5.63 (4.24, 6.69)
Negative LR: 0.76 (0.83, 0.70)

Problem 2 - Predict ILD Dx within 1 year following the Rheumatoid Arthritis Dx

Males:
AUC 77.2% (75.2%, 79.2%)
Sensitivity 35.4% (32.5%, 38.2%)
Positive LR: 7.00 (6.50, 7.64)
Negative LR: 0.68 (0.71, 0.65)

Females:
AUC 73.5% (71.8%, 75.2%)
Sensitivity 27.9% (25.7%, 30.1%)
Positive LR: 5.83 (5.15, 6.01)
Negative LR: 0.76 (0.78, 0.74)