IMUNOMODULADORES
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JOSÉ LUIZ INOJOSA
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23 de novembro de 2019
O PALESTRANTE
José Luis Inojosa
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Contexto
Contexto
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Lancet, 2018
Imunoterapia
CONTEXTO
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797370/neurohub_logo_final_fundo_claro__1_.png)
Interferonas - O que são?
- Interferonas ocorrem naturalmente na resposta imune no combate a patógenos;
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São citocinas especiais especialmente contra vírus;
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Tipos:
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Inteferon alfa
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Interferon gama
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Interferon beta
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Imunomodularores
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797370/neurohub_logo_final_fundo_claro__1_.png)
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797511/Captura_de_Tela_2019-11-20_às_05.08.22.png)
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![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797521/Captura_de_Tela_2019-11-20_às_05.11.18.png)
CONTEXTO
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Reduz a expressao de moléculas MHC II;
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Reduz citocinas inflamatórias;
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Reduz a proliferação celular da via TH1;
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Reduz a permeabilidade da BHE.
Interferonas - Mecanismos de Ação
Imunomodularores
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797370/neurohub_logo_final_fundo_claro__1_.png)
CONTEXTO
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797532/Captura_de_Tela_2019-11-20_às_05.14.13.png)
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797534/Captura_de_Tela_2019-11-20_às_05.14.20.png)
- Interferon beta 1a
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39mcg/sem IM
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22-44mcg/3xsem SC
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0,25mg/dias alt. SC
![](https://vidasuafanfarrona.files.wordpress.com/2017/10/20171027_174840_.jpg?w=656)
Interferonas - Apresentações
Imunomodularores
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CONTEXTO
- “SERENDIPIDADE” durante estudos em Encefalomielite Autoimune Experimental.
Imunomodularores
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797370/neurohub_logo_final_fundo_claro__1_.png)
CONTEXTO
Acetato de Glatiramera: O que são?
BARTHELMES, J 2016
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797562/Captura_de_Tela_2019-11-20_às_05.22.15.png)
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Polipeptídeo sintético L-glutâmico, L-lisina, L-alanina, L-tirosina;
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Mimetiza o fragmento 83-99 da proteína básica da mielina (MBP)
Ac. de Glatir. - Mecanismos de Ação
Imunomodularores
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797370/neurohub_logo_final_fundo_claro__1_.png)
CONTEXTO
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797572/Captura_de_Tela_2019-11-20_às_05.25.47.png)
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Acetato de Glatiramer 20mg/dia SC
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Acetato de Glatiramer 49mg/3xsem SC
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797578/Captura_de_Tela_2019-11-20_às_05.26.42.png)
Ac. de Glatir. - Apresentações
Imunomodularores
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797370/neurohub_logo_final_fundo_claro__1_.png)
CONTEXTO
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6792302/neurohub_logo_final_fundo_oscuro.png)
![](https://media3.giphy.com/media/gR8poD9TIQ6Zy/giphy.gif)
Uso
Uso
Quando Usar
USO
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Efeitos Colaterais
USO
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797370/neurohub_logo_final_fundo_claro__1_.png)
Glatiramer
LOCAIS:
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Dor
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Nódulos
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Lipodistrofia
SISTÊMICO/RARO:
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Opressão Torácica
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Taquicardia
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Benigna
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Evento ùnico em 50%
Efeitos Colaterais
USO
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797370/neurohub_logo_final_fundo_claro__1_.png)
Interferon
LOCAIS:
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Necrose (SC), abscesso (IM)
COMUNS:
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Sintomas flu-like
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Aumento de transaminases
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Linfopenia/anemia/plaquetopenia
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Depressão/Ideação Suicida
RAROS:
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Dist Tireoidiano
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Síndrome do Extravasamento Capilar Fatal
Barreira HE
USO
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797370/neurohub_logo_final_fundo_claro__1_.png)
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797611/Captura_de_Tela_2019-11-20_às_05.43.03.png)
Gravidez/Amam.
USO
![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797370/neurohub_logo_final_fundo_claro__1_.png)
Glatiramer
Interferonas
Vacinação
USO
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![](https://s3.amazonaws.com/media-p.slid.es/uploads/322027/images/6797621/Captura_de_Tela_2019-11-20_às_05.47.21.png)
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Discussões Atuais
Discussões Atuais
Conflito
Discussões Atuais
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PCDT
Discussões Atuais
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Aderência x Atuais
Discussões Atuais
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Janela Terapeutica
Discussões Atuais
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Intensidade
Discussões Atuais
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Considerações
Considerações
Tendências Atuais
Consideraçõe
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Indução
Manutenção
Obrigado
joseinojosa@neurohub.com.br
www.neurohub.com.br
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Copy of Copy of deck
By Neuro Hub
Copy of Copy of deck
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