Assessment of functional vision for daily life locomotion and navigation using VR
M.A. Safa Andac
Prof. Dr. Michael Hoffmann
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 955590.
Section for Clinical and Experimental Sensory Physiology
Otto-Von-Guericke University Magdeburg
Mr. Müller
Mr. Müller
- solo traveler
- into science a bit
- reads between the lines
Mr. Müller
Mr. Müller
- Likes to travel (a lot!)
- Into science a bit
- Reads between the lines
- glaucoma
Mr. Müller
- solo traveler
- into science a bit
- reads between the lines
- glaucoma
How well can I travel
considering the effect of glaucoma
on locomotion and navigation?
Outline
MOBILITY
- Glaucoma: one of the common causes of blindness worldwide
- Visual impairment increasing the risk of falling with age [1,2]
- Reduced movement in people with vision loss [2]
PATH INTEGRATION
PATH INTEGRATION
- Start from Point 0
- Move to Point 1
- Remember the position
- Move to Point 2 (second waypoint)
- Move to Point 3 (final waypoint)
- Point the position to be remembered
1
2
3
0
14 Glaucoma
15 Control (age-matched)
Lighting Conditions
PI
Cohort
PATH INTEGRATION : METHODS
No group effect
⇨
Accuracy
Euclidian Distance Error [vm]
PATH INTEGRATION : results
No group effect
⇨
Accuracy
Travel Time
Glaucoma is slower
⇨
Total Time for Travel [s]
Euclidian Distance Error [vm]
PATH INTEGRATION : results
PATH INTEGRATION : results
No group effect
⇨
Accuracy
Travel Time
Glaucoma is slower
⇨
Relation of time and pRNFL
⇨
Objective Relation
Total Time for Travel [s]
Total Time for Travel [s]
Euclidian Distance Error [vm]
- Insecurity in glaucoma patients makes them slower
- Trade-off between time and accuracy
- A possible relation between pRNFL and movement
PATH INTEGRATION : COnCLUSION
PATH INTEGRATION : COnCLUSION
Wait! I think I saw something
in the Figure 1
in the paper
- Insecurity in glaucoma patients makes them slower
- Trade-off between time and accuracy
- A possible relation between pRNFL and time
Full trajectory of a glaucoma
PATH INTEGRATION : COnCLUSION -- 2
Full trajectory of a glaucoma
PATH INTEGRATION : COnCLUSION -- 2
Full trajectory of a glaucoma
PATH INTEGRATION : COnCLUSION -- 2
Full trajectory of a glaucoma
What might the figure show us?
- Head sway
- Body sway
- Locomotion Pattern Change
PATH INTEGRATION : COnCLUSION -- 2
Full trajectory of a glaucoma
- Head sway
- Body sway
- Locomotion Pattern Change
Is there any movement difference between glaucoma and control?
What might the figure show us?
PATH INTEGRATION : COnCLUSION -- 2
LOCOMOTION
- Videos of 18 glaucoma and 30 control participants [1,2].
- Ophthalmic examination (i.e. ETDRS, IOP, VF, OCT)
- Measurements on treadmill at different speeds
- Visual Acuity (VA), Contrast Sensitivity (CS), Visual Field (VF)
LOCOMOTION: METHODS
LOCOMOTION : RESULTS
Classification using Videos in Visual Acuity Task
No difference between glaucoma and control
Classification using Videos in Visual Acuity Task
LOCOMOTION : RESULTS
LOCOMOTION : RECLASSIFICATION
- The cohort includes early-stage glaucoma
- PCA applied on OCT measures (retinal integrity)
- Pick 10 extreme from each end
PCA Result
Glaucoma
Control
Re-Classification using Videos in Visual Acuity Task
LOCOMOTION : RESULTS
Relationship between movement and pRNFL
Re-Classification using Videos in Visual Acuity Task
LOCOMOTION AND GLAUCOMA : RESULTS
SUMMARY
- Glaucoma is slower
- No difference between early glaucoma and control in locomotion
- BUT, a relation between pRNFL and movement
The locomotion changes in glaucoma might be reflected by pRNFL.
NAVIGATION
Locomotion
Navigation
NAVIGATION
Locomotion
Navigation
Walter, Jasmin L., et al. “Finding Landmarks - An Investigation of Viewing Behavior during Spatial Navigation in VR Using a Graph-Theoretical Analysis Approach.” PLOS Computational Biology, vol. 18, no. 6, June 2022.
NAVIGATION
Westbrück Virtual City
Glaucoma
Analysis
NAVIGATION
Westbrück Virtual City
Glaucoma
Analysis
Simulation
Peripheral - Central Scotoma
ACKNOWLEDGEMENT
THANKS!
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 955590.
DZNE
Wolber's Lab
Prof. Thomas Wolbers
Prof. Erhardt Barth
Yaxin Hu
Prof. Peter König
Jasmin L. Walter
Dr. David Mann
Kirsten Veerkamp
ACKNOWLEDGEMENT
THANKS!
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 955590.
DZNE
Wolber's Lab
Prof. Thomas Wolbers
Prof. Erhardt Barth
Yaxin Hu
Prof. Peter König
Jasmin L. Walter
Dr. David Mann
Kirsten Veerkamp
ACKNOWLEDGEMENT
DZNE
Wolber's Lab
Prof. Thomas Wolbers
Prof. Erhardt Barth
Yaxin Hu
Prof. Peter König
Jasmin L. Walter
Dr. David Mann
Kirsten Veerkamp
THANKS!
ACKNOWLEDGEMENT
DZNE
Wolber's Lab
Prof. Thomas Wolbers
Prof. Erhardt Barth
Yaxin Hu
Prof. Peter König
Jasmin L. Walter
Dr. David Mann
Kirsten Veerkamp
THANKS!
final-presentation-optivist
By Safa Andac
