Sex and gender dimension on data
Data tagging
Good practice is to associate data to community accepted ontologies (very well know case: Gene Ontology)
Creating a Queer Ontology: The Gender, Sex, and Sexual Orientation (GSSO) Ontology
Sex and gender dimension on data
Sex identification/prediction
If no available metadata on sex
massiR: a method for predicting the sex of samples in gene expression microarray datasets
Bioconductor package
Otherwise, other Gene Enrichment methods
Sex and gender dimension on data
Sex identification/prediction
If no or little information of reference genome / chromosome structure
Fully automated pipeline for detection of sex linked genes using RNA-Seq data
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-015-0509-0
Galaxy pipeline
Sex and gender dimension on data
Sex identification/prediction
Sex-biased differential expression
SAGD: a comprehensive sex-associated gene database from transcriptomes
https://academic.oup.com/nar/article/47/D1/D835/5150230
Sex and gender dimension on data
Sex identification/prediction
There may be unexpected scenarios in some organisms!
Sex-biased gene expression is repeatedly masculinized in asexual females
https://www.nature.com/articles/s41467-019-12659-8
Sex and gender dimension on data
Sex and gender differences and biases in artificial intelligence for biomedicine and healthcare
https://www.nature.com/articles/s41746-020-0288-5
Resulting biases
Sex and gender dimension on data (CRG - June 2021)
By Similis.cc
Sex and gender dimension on data (CRG - June 2021)
Some slides for the session on "sex and gender dimension on data" organized by The CRG Gender Balance Committee
