A BIG THANKYOU

•  Thank you to Dr. Anand Dubey, Mr. Nikhil Gopinath, and Prof Chandrabose for providing their technical inputs and for reviewing our work
• Thank you to Malaikannan, for bringing us together as a team and leading our research from end to end

Why Study DNA Methylation?

Gene in the Normal Cell

Gene in the Cancer Cell

Lam K, et al., 2016

• 32 diseases

• 10,000 samples

• Rows: 365860
• Converted into a matrix of shape (220,1663)

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Data Pre Processing

• Base CNN- This was a vanilla CNN with 3X3 filters; 3 filter layers; 10 filters in each layer

• CNN Width: Rectangular filter with window sizes 1, 3, 5, 7

• CNN Height and Width: Combination of both height-wise and width-wise filter of windows 1, 3, 5, 7

• CNN Height: Height-wise filters of window 1, 3, 5, 7.

Training Approach 

Model Accuracy