Daniel Himmelstein
Head of Data Integration at Related Sciences. Digital craftsman of the biodata revolution.
July 8, 2015
Daniel Himmelstein
Sergio Baranzini Lab
network of pathogenesis:
classifier:
mechanisms of pathogenesis:
gold standard for our supervised approach
aggregated 4 resources:
MEDI-HPS – combines RxNorm, MedlinePlus, SIDER 2, and Wikipedia
ehrlink – linked data from health records
LabeledIn – expert and MTurk curated drug labels
PREDICT – UMLS links, drugs.com, drug labels
1,388 high and 1,114 low-confidence indications
We combine all signatures for each DrugBank compound to get a consensus signature
http://thinklab.com/d/67
Bgee
curates microarray and RNA-Seq experiments
http://bgee.unil.ch/
TISSUES
transcriptomics, proteomics, text mining, UniProtKB
http://tissues.jensenlab.org/About
http://thinklab.com/d/81
http://thinklab.com/d/81#293
http://thinklab.com/d/81#293
depletion is more common than enrichment
highly-specialized tissues have the greatest differential expression
By Daniel Himmelstein
Presentation to the Atul Butte group at UCSF on July 8, 2015
Head of Data Integration at Related Sciences. Digital craftsman of the biodata revolution.