Understanding epidemiological and macroevolutionary processes using novel phylogenetic and phylodynamic methods

Nicola Felix Müller

Phylogenetic trees denote the evolutionary relationship between individuals

The shape of these trees tells us something about the population process that created them

Inferring how lineages coalesce within and migrate between sub-populations

  • N. F. Müller, D. A. Rasmussen, T. Stadler (2017), Molecular Biology and Evolution.
  • N. F. Müller, D. A. Rasmussen, T. Stadler (2018), Bioinformatics.
  • N. F. Müller, G. Dudas, T. Stadler (2019), Virus Evolution.

Methods that allow accounting for population structure typically require to infer where lineages have been in the past

Müller et al., 2017, Mol. Biol. Evol.

Different approaches to integrate over migration histories can lead to vastly different inference results

Müller et al., 2017, Mol. Biol. Evol.

The marginal approximation of the structured coalescent of the structured coalescent allows accounting for population structure

Müller et al., 2017, Bioinformatics

MASCOT allows efficiently inferring where lineages were in the past, rates of migration between sub-populations and their population sizes

Müller et al., 2017, Bioinformatics

By defining rates of coalescence and migration as log-linear combinations of predictors data, indicators and coefficients, we can jointly infer migration and coalescence patterns and what predicts them

Müller et al., 2019, Virus Evolution

Inferring how lineages coalesce within and migrate between sub-populations

  • N. F. Müller, D. A. Rasmussen, T. Stadler (2017), Molecular Biology and Evolution.
  • N. F. Müller, D. A. Rasmussen, T. Stadler (2018), Bioinformatics.
  • N. F. Müller, G. Dudas, T. Stadler (2019), Virus Evolution.

The shared evolutionary history of individuals from different species does not describe the history of species

The shared evolutionary history of individuals from different species does not describe the history of species

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By Nicola Mueller

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