Wnd-charm on Parkinson
A biological model
Parkinson disease
Parkinson disease
1.5% > 65 years
10% linked to genetic cause
10-20%
LRRK2 mutation
IPS to cellular model
IPS to cellular model
CRISPR-Cas on LRRK2 gene
Rescued IPS
Patient IPS
Sick neuron
Rescued neuron
Screening
Feature enginereeing
CP-Charm
Feature pre-processing
Normalisation - outliers
Classification
LDA
Confusion matrix
Most discriminant features
Most discriminant features
Correlation matrix of most discriminant features
5364.87463964 Histogram_5BinsHistBin1_In_ch1
1443.84972274 Histogram_5BinsHistBin1_In_ch2
1126.5534813 Histogram_7BinsHistBin3_In_ch1
857.428781402 Histogram_5BinsHistBin1_InFourierCheby_ch2
702.784095987 Histogram_9BinsHistBin8_InFourierCheby_ch2
634.761936248 Histogram_5BinsHistBin4_InCheby_ch3
355.090006333 Histogram_9BinsHistBin6_InCheby_ch2
226.195011004 Texture_Correlation_InFourierCheby_3_135_ch2
225.924452444 Histogram_5BinsHistBin4_In_ch3
192.990171017 Histogram_7BinsHistBin6_InFourierCheby_ch2
141.585470492 Histogram_7BinsHistBin2_InFourierCheby_ch3
86.3998204407 Histogram_7BinsHistBin2_In_ch2
45.2902999552 Histogram_7BinsHistBin6_In_ch3
44.0662239657 Histogram_9BinsHistBin8_InFourierCheby_ch1
34.4751239737 Histogram_5BinsHistBin4_InWavelet_ch3
28.9275715362 Histogram_3BinsHistBin2_InWavelet_ch3
24.2660167788 Texture_Correlation_InFourierCheby_3_0_ch1
18.5950608401 Histogram_9BinsHistBin0_InFourierCheby_ch2
17.7194797542 Texture_Correlation_InFourierCheby_3_135_ch1
16.9588356479 Texture_InfoMeas1_InFourierCheby_3_45_ch1
15.7210947226 Texture_SumVariance_InCheby_3_45_ch2
15.5599552626 Histogram_9BinsHistBin8_InFourier_ch2
14.4957496539 Texture_Contrast_InCheby_3_45_ch2
14.3773978707 Histogram_9BinsHistBin2_InFourier_ch2
14.3489670996 Texture_InfoMeas1_InCheby_4_90_ch1
13.0397767387 Texture_Tamura_CoarsenessHist_3BinsHist_Bin1_InWavelet_ch1
12.7703750113 Histogram_32BinsHistBin6_FourierChebyStats_ch3
12.3404182008 Texture_Tamura_CoarsenessHist_3BinsHist_Bin1_InWavelet_ch2
Most discriminant features
Thank you !
deck
By Tiphaine Champetier
