Thesis Updates

Purpose of Meeting

• Update progress on Aim 1
• Rationale for revisions with Aim 2
  • and deletion of Aim 3
• Suggestions/Concerns for revisions
• Goal for Graduation (Summer 2020)

Overall Thematic Changes

Beta Series Primer

Aim 1:

Create and validate NiBetaSeries to perform beta series correlations

Methods

• Create NiBetaSeries
• Simulate correlations
• Task versus Rest Data
• Task versus "Pseudo Task" Data

NiBetaSeries

• Generates beta maps and creates correlations
• multiple tests to ensure functionality (88% coverage of code)
  • travis ci
  • circle ci
• documentation (and a tutorial)
• deployed with python and dockerhub
• contributions from around the world
• published in journal of open source software (JOSS)

Simulations

Task versus Rest

• Question: Do beta series correlations detect task condition differences in a cognitive control task? 
• 61 older adults (65+)
• Task Switch Task
  • ~40 switch trials
  • ~40 repeat trials
  • Intertrial interval ~ 3.5 seconds

Task versus Rest

Task versus Rest

Task versus Rest

Task versus Rest

-

-

~  0.1

~  0.0

Power Analysis: Aim 1

Task versus "Pseudo-Task"

• Question: Are beta series correlations only driven by the magnitude of the BOLD response? 
• 61 older adults (65+)
• Task Switch Task
  • ~40 switch trials
  • ~40 repeat trials

Task versus "Pseudo Task"

Task versus "Pseudo Task":

Model the average response to each task condition for every voxel

Task versus "Pseudo Task"

+

+

+

+

+

+

+

Task versus "Pseudo Task"

Task versus "Pseudo Task" versus Rest: Aim 1

Aim 1: Questions?

Aim 2:

Characterize the relationship between beta series correlations and residual correlations during a flanker task.

Methods

• OpenNeuro ds001751
• Flanker Task
  • 4 trial types
    • MI-C: 48 trials
    • MI-I: 192 trials
    • MC-C: 192 trials
    • MC-I: 48 trials
  • Inter-Trial Interval ~ 3.0 seconds

Methods Cont.

Residual Correlations

Residual Correlations

Task Onsets

Task Beta Estimates

Residual Correlations

 - 

=

Residual Correlations

Predictions: Aim 2

Quesions: Aim 2?

What about Aim 3?

• behavioral results of ds001751 are known

Next Steps

• Follow up on simulation findings
• create the pseudo data and analyze
• write and submit paper
  • "PLOS-ONE"
  • "Frontiers in Systems Neuroscience"
• run ds0001751
  • through fmriprep
  • through nibetaseries
• Write Thesis

Questions/Feedback