So noisy, 

so good.


Javier Garcia-Bernardo       

Computer Science Master Student              

Math 303. Complex Networks              


Background

Genetic networks

Single input motifs

Downstream Gene Expression

Small fluctuations in Activator

Coordination

 

Coordination is good

Noise in Gene Expression


Intrinsic: Affect to only one gene.

E.g. RNApolymerase binding to a promoter

Inherent to the Gillespie Algorithm


Extrinsic: Affect to all genes

E.g. Fluctuations in the levels of the RNApolymerase

Modelled with a Ornstein–Uhlenbeck process




Emergence of Coordination

from noise in gene expression


TATA box example


Lots of genes in stress response in yeast have a TATA box.

Is that advantage due to coordination?

Has noise evolved?

Wow

Conclusions


Small fluctuations in the Activator

coordinate expression of Downstream genes.


Even Infrequent coordination helps to bet-hedge

against sudden changes in the environment.


They do this without cost (Not shown).


Noise can produce the fluctuations.



Emergence

By Javier GB

Emergence

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