Computer Science Master Student
Math 303. Complex Networks
Single input motifs
Downstream Gene Expression
Small fluctuations in Activator
Coordination is good
Noise in Gene Expression
Intrinsic: Affect to only one gene.
E.g. RNApolymerase binding to a promoter
Inherent to the Gillespie Algorithm
Extrinsic: Affect to all genes
E.g. Fluctuations in the levels of the RNApolymerase
Modelled with a Ornstein–Uhlenbeck process
Emergence of Coordination
from noise in gene expression
TATA box example
Lots of genes in stress response in yeast have a TATA box.
Is that advantage due to coordination?
Has noise evolved?
Small fluctuations in the Activator
coordinate expression of Downstream genes.
Even Infrequent coordination helps to bet-hedge
against sudden changes in the environment.
They do this without cost (Not shown).
Noise can produce the fluctuations.
By Javier GB