Imaging Biomaterial-Tissue Interaction

Yu Shrike Zhang & Junjie Yao  2017 Oct 17.

• spatial resolution
• penetration depth
• temporal response
• detection sensitivity
• chemical specificity

engineering approaches

+

Ultrasound (US)

PRO

• safest
• high speed
• deep penetration

CON

• low resolution 
• low chemical sensitivity
• coupling medium needed

Application

• mechanics
• flow dynamics
• scaffold cavitation

Magnetic Resonance Imaging (MRI)

PRO

• deep penetration

CON

• expensive
• low imaging speed
• strong magnetic field (unknown)

Application

• water content and transport

Optical Imaging

Confocal Microscopy (CM)

Multi-proton Microscopy (MPM)

Photoacoustic Tomography (PAT)

Optical Coherence Tomography (OCT)

High-energy Electromagnetic Waves

X-ray

Scanning Electron Microscopy (SEM)

Transmission Electron Microscopy (TEM)

Positron-emission Tomograph (PET)

Single-photon Emission Computed Tomography (SPECT)

限制

難以同時讓biomaterial 和biological entities成像

解決

exogenously introduced contract mechanism

為了形成對比，不同造影方法間的搭配與進展

近期的進步

CLARITY

&

Expansion Microscopy (ExM)

Conclusion

• 除了適當的contrast mechanism之外，還有很多辦法能提升影像清晰度
• the development of specialized multi-modality imaging systems and multiplexed contrast mechanisms