Acknowledgements

Monies!

NSF CAREER (CBET-1351692), NSF BRAIN
EAGER  (IOS-1550994), HFSP Young Investigator’s (RGY0088)

Lab

Dr. Caleb Kemere

Josh, Ziying, Sibo, Della, Kayla, Dani, Amy

Former: Jim, Ariel, Etienne, Alex, James, Jill, Eric

Interrogating the role of hippocampal sharp-wave ripples in spontaneous learning

Shay(ok) Dutta

Interface Rice 2023

May 19, 2023

Will Smith...

What is the neural substrate for storing the configuration of the world?

Will Smith --> Rats

What is the neural substrate for storing the configuration of the world?

Where to begin?

Active Behavior

Quiescence

hmm...

Where to begin?

Quiescence

hmm...

Active Behavior

What does this look like?

Just Rat Hippocampus

Are SWRs related to storing the configuration of the world?

How can we test this?

Dutta et al. JNE 2018

ORM No More!

Are SWRs related to storing the configuration of the world?

YES!

Conclusions

Cool stuff! Come check out poster 9!

  • Causal relationship established between hippocampus and object-location memory
  • First ripple disruption task that can be run repeatedly with chance level performance!
    • New memory formation, consolidation and place field stability questions can be asked!
  • First ripple disruption task with result with a behavioral effect that is in shown in a natural, foraging, curiosity driven behavior innate across animals!
  • Longer ripples clearly have some relationship with better memory consolidation but all ripples are matter for consolidation!

InterfaceRice2023-LightningTalk!

By Shayok Dutta

InterfaceRice2023-LightningTalk!

This presentation explores the role of hippocampal sharp-wave ripples in spontaneous learning, with a particular focus on object recognition memory.

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